陈晓岗-CSCIED科技核心评价数据库-手机版

单位：中南大学湘雅二医院

研究方向：精神病学

社会任职
中南大学湘雅二医院精神科主任医师、教授、博导，湘雅二医院精神卫生研究所图书情报室主任，精神病学与精神卫生学湖南省重点实验室主任。兼任《国际精神病学杂志》主编、JPBS杂志主编。主持NIH国际合作课题1项、国家自然科学基金课题 5 项，参与国家自然科学基金重点课题 2项，参与 973项目2项，获湖南省科学技术进步二等奖 2项，主编专著 1 部，获湖南省科技进步二等奖一项，国家发明专利一项，以通讯作者在JAMA Psychiatry、Molecular Psychiatry、Schizophrenia Bulletin、Science Bulletin等国内外高水平SCI杂志上发表论文60余篇；

个人介绍
《国际精神病学杂志》主编； Journal of Psychiatry & Brain Science杂志主编； Scientific Reports 杂志编委;

高被引文献
最新文献
合作学者

1. Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis

[学者论文] RS评分：9

作者： Ying He, Tomasz Kosciolek, Jinsong Tang, Yao Zhou, Zongchang Li, Xiaoqian Ma, Qiyun Zhu, Ning Yuan, Liu Yuan, Chunwang Li, Ke Jin, Rob Knight, Ming T Tsuang, Xiaogang Chen

《European Psychiatry》2018年 53卷期

摘要：Background: The microbiota-gut-brain axis and membrane dysfunction in the brain has attracted increasing attention in the field of psychiatric research. However, the possible interactive role of gut microbiota and brain function in the prodromal stage of schizophrenia has not been studied yet. Methods: To explore this, we collected fecal samples and performed Magnetic Resonance Spectroscopy (MRS) scans in 81 high risk (HR) subjects, 19 ultra-high risk (UHR) subjects and 69 health controls (HC). Then we analyzed the differences in gut microbiota and choline concentrations in the anterior cingulate cortex (ACC). Results: Presences of the orders Clostridiales, Lactobacillales and Bacteroidales were observed at increase levels in fecal samples of UHR subjects compared to the other two groups. The composition changes of gut microbiota indicate the increased production of Short Chain Fatty Acids (SCFAs), which could activate microglia and then disrupt membrane metabolism. Furthermore, this was confirmed by an increase of choline levels, a brain imaging marker of membrane dysfunction, which is also significantly elevated in UHR subjects compared to the HR and HC groups. Conclusion: Both gut microbiome and imaging studies of UHR subjects suggest the membrane dysfunction in the brain and hence might support the membrane hypothesis of schizophrenia.

关键词：Schizophrenia,Ultra-high risk,Microbiome,Magnetic resonance spectroscopy

浏览量: 645 下载: 3 发表时间：2018/9/1 0:00:00

HTML阅读下载引用收藏
2. A review of the functional and anatomical default mode network in schizophrenia

[学者论文] RS评分：0

作者： Mao-Lin Hu, Xiao-Fen Zong, J John Mann, Jun-Jie Zheng, Yan-Hui Liao, Zong-Chang Li, Ying He, Xiao-Gang Chen, Jin-Song Tang

《Neuroscience bulletin》2017年 33卷 1期

摘要：Schizophrenia is a severe mental disorder char- acterized by impaired perception, delusions, thought dis- order, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network (DMN), since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correla- tion with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and con- sider the DMN effects of individualized therapies for schizophrenia.

关键词：Schizophrenia, Default mode network, Task- negative network, Task positive network, Antipsychotics, Resting state, fMRI, DTI

浏览量: 495 下载: 0 发表时间：2016/12/19 0:00:00

HTML阅读下载引用收藏

1. Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis

2. A review of the functional and anatomical default mode network in schizophrenia