Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis-CSCIED科技核心评价数据库-手机版

Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis

Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis

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DOI	https://doi.org/10.1016/j.eurpsy.2018.05.011
刊名	European Psychiatry
年，卷(期)	2018, 53()
作者	Ying He, Tomasz Kosciolek, Jinsong Tang, Yao Zhou, Zongchang Li, Xiaoqian Ma, Qiyun Zhu, Ning Yuan, Liu Yuan, Chunwang Li, Ke Jin, Rob Knight, Ming T Tsuang, Xiaogang Chen,
作者单位	aDepartment of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China fMental Health Institute of Central South University, Changsha, Hunan, 410011, China gChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, 410011, China hChina National Technology Institute on Mental Disorders, Changsha, Hunan, 410011, China
摘要	Background: The microbiota-gut-brain axis and membrane dysfunction in the brain has attracted increasing attention in the field of psychiatric research. However, the possible interactive role of gut microbiota and brain function in the prodromal stage of schizophrenia has not been studied yet. Methods: To explore this, we collected fecal samples and performed Magnetic Resonance Spectroscopy (MRS) scans in 81 high risk (HR) subjects, 19 ultra-high risk (UHR) subjects and 69 health controls (HC). Then we analyzed the differences in gut microbiota and choline concentrations in the anterior cingulate cortex (ACC). Results: Presences of the orders Clostridiales, Lactobacillales and Bacteroidales were observed at increase levels in fecal samples of UHR subjects compared to the other two groups. The composition changes of gut microbiota indicate the increased production of Short Chain Fatty Acids (SCFAs), which could activate microglia and then disrupt membrane metabolism. Furthermore, this was confirmed by an increase of choline levels, a brain imaging marker of membrane dysfunction, which is also significantly elevated in UHR subjects compared to the HR and HC groups. Conclusion: Both gut microbiome and imaging studies of UHR subjects suggest the membrane dysfunction in the brain and hence might support the membrane hypothesis of schizophrenia.
Abstract	Background: The microbiota-gut-brain axis and membrane dysfunction in the brain has attracted increasing attention in the field of psychiatric research. However, the possible interactive role of gut microbiota and brain function in the prodromal stage of schizophrenia has not been studied yet. Methods: To explore this, we collected fecal samples and performed Magnetic Resonance Spectroscopy (MRS) scans in 81 high risk (HR) subjects, 19 ultra-high risk (UHR) subjects and 69 health controls (HC). Then we analyzed the differences in gut microbiota and choline concentrations in the anterior cingulate cortex (ACC). Results: Presences of the orders Clostridiales, Lactobacillales and Bacteroidales were observed at increase levels in fecal samples of UHR subjects compared to the other two groups. The composition changes of gut microbiota indicate the increased production of Short Chain Fatty Acids (SCFAs), which could activate microglia and then disrupt membrane metabolism. Furthermore, this was confirmed by an increase of choline levels, a brain imaging marker of membrane dysfunction, which is also significantly elevated in UHR subjects compared to the HR and HC groups. Conclusion: Both gut microbiome and imaging studies of UHR subjects suggest the membrane dysfunction in the brain and hence might support the membrane hypothesis of schizophrenia.
关键词	Schizophrenia,Ultra-high risk,Microbiome,Magnetic resonance spectroscopy
KeyWord	Schizophrenia,Ultra-high risk,Microbiome,Magnetic resonance spectroscopy
基金项目
页码	37-45

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Ying He, Tomasz Kosciolek, Jinsong Tang, Yao Zhou, Zongchang Li, Xiaoqian Ma, Qiyun Zhu, Ning Yuan, Liu Yuan, Chunwang Li, Ke Jin, Rob Knight, Ming T Tsuang, Xiaogang Chen. Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis [J]. European Psychiatry. 2018; 53; (). 37 - 45.

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2025-12-16 10:03:28

此文对肠道菌群与脑膜功能障碍进行了较为深入的研究，为此类疾病的治疗研究提供了有益的数据支撑。此文被引已达130多次，影响较为广泛。

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