A review of the functional and anatomical default mode network in schizophrenia-CSCIED科技核心评价数据库-手机版

A review of the functional and anatomical default mode network in schizophrenia

A review of the functional and anatomical default mode network in schizophrenia

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DOI	10.1007/s12264-016-0090-1
刊名	Neuroscience bulletin
年，卷(期)	2017, 33(1)
作者	Mao-Lin Hu, Xiao-Fen Zong, J John Mann, Jun-Jie Zheng, Yan-Hui Liao, Zong-Chang Li, Ying He, Xiao-Gang Chen, Jin-Song Tang,
作者单位	1 Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha 410011, China 2 Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry and Radiology, Columbia University, New York, NY 10032, USA 3 Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, The Second Xiangya Hospital of Central South University, Changsha 410011, China 4 Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology and Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 611731, China 5 Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience, David Geffen School of Medicine, Los Angeles, CA 90024, USA
摘要	Schizophrenia is a severe mental disorder char- acterized by impaired perception, delusions, thought dis- order, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network (DMN), since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correla- tion with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and con- sider the DMN effects of individualized therapies for schizophrenia.
Abstract	Schizophrenia is a severe mental disorder char- acterized by impaired perception, delusions, thought dis- order, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network (DMN), since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correla- tion with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and con- sider the DMN effects of individualized therapies for schizophrenia.
关键词	Schizophrenia, Default mode network, Task- negative network, Task positive network, Antipsychotics, Resting state, fMRI, DTI
KeyWord	Schizophrenia, Default mode network, Task- negative network, Task positive network, Antipsychotics, Resting state, fMRI, DTI
基金项目
页码	73-84

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引用本文

Mao-Lin Hu, Xiao-Fen Zong, J John Mann, Jun-Jie Zheng, Yan-Hui Liao, Zong-Chang Li, Ying He, Xiao-Gang Chen, Jin-Song Tang. A review of the functional and anatomical default mode network in schizophrenia [J]. Neuroscience bulletin. 2017; 33; (1). 73 - 84.

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