帕金森病伴抑郁患者的中西结合治疗效果观察

Observation on therapeutic effect of combination of Chinese traditional and Western medicine in patients with Parkinsons disease and depression

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2017, 44(5)
作者
作者单位

福建三明市中西医结合医院神经内科 ;

摘要
【摘要】探讨疏肝解郁胶囊联合帕罗西丁治疗帕金森病伴抑郁的疗效及不良反应。方法 选取我院在2014年3月-2016年8月期间收治 80 例帕金森病伴抑郁患者,将其随机分为观察组(n=40)和对照组(n=40),对照组 40例患者给予帕罗西丁治疗。观察组 40 例在对照组的治疗基础上加疏肝解郁胶囊治疗。对比观察两组临床治疗效果及其不良反应表现。结果观察组患者的UPDRS Ⅰ、UPDRS Ⅱ、UPDRS Ⅲ、UPDRS Ⅳ、HAMD评分均显著低于对照组(P<0.05),观察组治疗总有效率90.0%显著高于对照组70.0%,且观察组患者的不良反应发生率35.0%显著低于单纯西医治疗组75.0%,两组比较具有统计学意义(P<0.05)。结论 疏肝解郁胶囊联合帕罗西丁治疗帕金森病抑郁状态具有良好的临床疗效,同时能改善患者帕金森病神经症状,且不良反应少,值得在临床上进一步推广应用。
Abstract
【Abstract 】 Objective To investigate the liver capsule joint resolve depression paro cefoxitin treatment the curative effect of Parkinsons disease with depression and adverse reactions. Methods Selected our hospital in March 2014 - August 2016 treated 80 cases of patients with Parkinsons disease with depression, which were randomly divided into observation group (n = 40) and the control group (n = 40), the control group of 40 cases with matteo paro cefoxitin treatment. On the basis of observation group of 40 cases in the control group treatment and liver resolve depression capsule treatment. Contrast observed two groups of clinical curative effect and adverse reactions. Results The observation group of patients with UPDRS Ⅰ, UPDRS Ⅱ, UPDRS Ⅲ, UPDRS Ⅳ, HAMD scores were significantly lower than control group (P < 0.05), the observation group is significantly higher than the control group total effective rate 90.0%, and the observation group of patients the incidence of adverse reactions was significantly lower than 35.0% pure western medicine treatment group was 75.0%, comparing the two groups have statistical significance (P < 0.05). Conclusion Liver capsule combined therapy with matteo paro cefoxitin resolve depression depression has good clinical curative effect of Parkinsons disease, and can improve the symptoms of Parkinsons disease patients with nerve, and less adverse reactions, worthy of further popularization and application in clinic.
关键词
【关键词】帕金森病;抑郁;帕罗西丁;疏肝解郁胶囊
KeyWord
[Key words] Parkinson disease;Depression; Paroxetine; Shugan Jieyu capsule;
基金项目
页码 819-921
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刘尧斌*,纪家镛,叶剑鹏,唐瑾,苏文理. 帕金森病伴抑郁患者的中西结合治疗效果观察 [J]. 国际精神病学杂志. 2017; 44; (5). 819 - 921.

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