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[Abstract] Objective To investigate the correlation of peripheral blood oxidative stress factors, IL-6, S100-β and NT-3 in patients with schizophrenia, and to provide a theoretical basis for the diagnosis and treatment of schizophrenia patients. Methods This study object included 50 cases of patients with schizophrenia and 30 cases of normal people who were treated in our hospital from December 2015 -December 2016, patients were divided into the observation group and the control group. Patients in the observation group were further divided into the positive symptoms group ( positive symptoms mainly )and the negative symptoms group ( negative symptoms mainly) through scores of schizophrenic symptoms (positive and negative syndrome scale, PANSS) ,peripheral blood oxidative stress factors such as SOD, GSH-Px, NO,LPO, GSH of the two groups were detected , and protein factor concentration level of serum S100-P, IL-6 and NT-3 were detected .Correlation analysis was performed by Pearson correlation analysis. Results Total score of PANSS, positive score of the positive symptoms group were significantly higher than those of the negative symptoms group, negative symptoms score was significantly lower than that of the negative symptoms group, there was statistical significance (P<0.05),the general symptom score had no significant difference (P>0.05); SOD, NO,GSH-Px showed no significant difference between the positive symptoms group and the negative symptoms group,there were significant differences with the control group in addition to LPO, GSH , showing statistical significance (P<0.05);S100-P, NT-3 of the positive symptoms group and the negative symptoms group had no significant difference (P>0.05), IL-6 was significantly lower than that of the control group, and data of the two groups showed significant difference with that of the control group , there was statistical significance (P<0.05); Among all the indexes, the concentration of NO was negatively correlated with total PANSS score in schizophrenia patients and general symptoms scores(r=0.354, r=0.342, P<0.05) ,SOD had positive correlation with PANSS scores of schizophrenic patients and general symptoms scores (r=0.354, (r=0.389, P<0.05), NT-3 showed positive correlation with general symptoms of the positive symptoms group (r=0.376, P<0.05), there was no correlation between other indexes (P>0.05). Conclusion The occurrence and development of schizophrenia may be related to oxidative stress factor, IL-6, S100- beta, NT-3, and mental symptom has a close relationship with SOD , NO and NT-3 .
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