| Abstract |
Objective: To explore the efficacy of different anti-depressant drugs in the glycolipid metabolism for depression patients. Methods: 240 depression patients were randomly assigned to three groups, 80 cases each group. Patients took the Sertraline, Citalopram or Mirtazapine, respectively. The HAMD (Hamilton Depression Scale) points, blood glucose level and blood lipid levels were counted. Results: After 4w and 8w of treatment, the HAMD points for three groups were significantly lower than before (P＜0.05); The HAMD points in the Mirtazapine group were lower than Citalopram group and Sertraline group (P＜0.05); after 4w and 8w of treatment, the HAMD points in the Citalopram group and Sertraline group were not significantly different (P＞0.05); after 4w and 8w of treatment, the index of 2hPG (2 hour plasma glucose), FPG (fasting plasma glucose),TC (total cholesterol) and TG (triglyceride) in the Mirtazapine group and Citalopram group were significantly higher than Sertraline group (P＜0.05); after 4w and 8w of treatment, the index of 2hPG, FPG, TC and TG in the Mirtazapine group and Citalopram group were not significantly different (P＞0.05); before treatment and after 4w, 8w of treatment, the index of 2hPG, FPG, TC and TG in the Sertraline group were not significantly different (P＞0.05).Conclusion: Sertraline, Citalopram and Mirtazapine have the fair effect in depression patients. However, Mirtazapine and Citalopram produce a larger effect in the glycolipid metabolism. It shall be recommended in clinical practice.
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