| Abstract |
Objective To investigate the correlation between changes in serum C-reactive protein (CRP), albumin (Alb), and prealbumin (PA) levels and the Hamilton Depression Scale (HAMD) score in patients with depression. Methods From December 2017 to November 2019, 91 patients with depression in our hospital were selected as the study group, and 42 healthy patients who were examined during the same period were used as the control group. All serum CRP, Alb, PA, and tumor necrosis factor-α (TNF-α) levels were measured, and serum CRP, Alb, PA, and TNF-α levels were compared between the two groups; HAMD scores were given to patients with depression, and venlafaxine hydrochloride sustained-release tablets were given, the serum CRP, Alb, PA, and TNF-α levels of patients with different HAMD scores and those who were effective and ineffective after 3 months of treatment were compared, and the correlation between serum CRP, Alb, PA, and TNF-α levels and HAMD scores was analyzed. Results The levels of serum CRP and TNF-α in the study group were higher than those in the control group, and the levels of serum Alb and PA were lower than those in the control group (P＜0.05); there were significant differences in serum CRP, Alb, PA and TNF-α levels in patients with different HAMD scores (P<0.05); according to Pesrson analysis, serum CRP (r=0.651) and TNF-α (r=0.477) levels were positively correlated with HAMD scores, while serum Alb (r=-0.782) and PA (r=-0.419) were negatively correlated with HAMD scores (P<0.05); after 3 months of treatment, the serum CRP and TNF-α levels of patients who were effective were lower than those of ineffective patients, and the serum Alb and PA were higher than those of ineffective patients (P<0.05). Conclusion Serum CRP and TNF-α are highly expressed in patients with depression, and are positively correlated with HAMD scores in patients with depression, serum Alb and PA are lowly expressed in patients with depression, and negatively correlated with HAMD scores in patients with depression. Detection of serum CRP, TNF-α, Alb, PA levels can be used to assess the severity of depression in patients with depression, providing an effective reference for clinical diagnosis and treatment.
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