Journal of International Psychiatry

Objective:To explore the characteristics of TNF-α levels and their correlation with cognitive function in patients with post-stroke depression. Methods: Study group: 42 patients with depressive episodes within six months after stroke. Control group: 40 healthy adults. ELISA was used to detect serum TNF-α levels in the study group and the control group. Working memory and strategy application (SWM) in the Cambridge Neuropsychological Test (CANTAB) were used to test cognitive function in the study group and the control group, respectively. The content includes search errors within groups, search errors between groups, strategy application, and average response time. Results: Before treatment, the levels of serum TNF-α in patients with post-stroke depression were higher than those in the control group, and the difference was statistically significant (P <0.05). In the cognitive test (SWM), search errors within the group and search errors between groups The study group and strategy application study group were higher than the control group, and the difference was statistically significant (P <0.05). Correlation analysis found that serum TNF-α levels in the study group and search errors within the SWM group, search errors between groups, and strategy application There was a positive correlation with the average response time (P <0.01). Conclusion: This study found that serum TNF-α levels increased and cognitive function decreased in patients with post-stroke depression, suggesting that TNF-α may be involved in the occurrence of post-stroke depression. Correlation analysis found that TNF-α levels may mediate cognitive decline.

Post-stroke depression；Tumor necrosis factor；Cognitive function