The Effects of Amplitude-Based Training on Mobility, Functional Leg Strength, and Balance Confidence in Persons with Parkinson’s Disease with and Without Deep Brain Stimulation: A Case Series-Advances in Geriatric Medicine and Research-CSCIED科技核心评价数据库-手机版

The Effects of Amplitude-Based Training on Mobility, Functional Leg Strength, and Balance Confidence in Persons with Parkinson’s Disease with and Without Deep Brain Stimulation: A Case Series

The Effects of Amplitude-Based Training on Mobility, Functional Leg Strength, and Balance Confidence in Persons with Parkinson’s Disease with and Without Deep Brain Stimulation: A Case Series

ES评分 0 浏览量：238 下载量：0

全文阅读下载引用收藏

DOI	10.20900/agmr20250006
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2025, 7(2)
作者	Rosemary Lackey Babcock,Abigail Anderson,Laurie Neely*,Christina Speranza,Caitlyn Wilkerson,Jennifer Tolle,Kathleen Salik,Rolando Lazaro,Morris Casano Beato,
作者单位	Select Physical Therapy, 501 East Oak Street, Suite D, Kissimmee, FL 34744, USA ; Doctor of Physical Therapy Program, Division of Physical Therapy, School of Kinesiology & Rehabilitation Sciences ; Banner Physical Therapy in Partnership with Select Medical, 5605 Eugie Avenue, suite 215, Glendale, AZ 85304, USA ; Department of Physical Therapy, College of Health and Human Services, California State University, 6000 J Street, Sacramento, CA 95819, USA ;
摘要	Background and Introduction: As the prevalence of Parkinson’s disease (PD) increases, novel treatment methods are sought to slow the disease progression. Because medication loses effectiveness with prolonged use, deep brain stimulation (DBS) can become a surgical option. There are positive outcomes with the use of amplitude-based training (ABT) as treatment for persons with PD (PwPD), but little research has been done to support its effectiveness for individuals with DBS. Purpose: The purpose of this retrospective case series is to investigate the effects of ABT on people with and without DBS. We hypothesize that ABT will produce improvements on mobility outcomes in PwPD regardless of DBS status. Methods: Data was collected from 7 PwPD with DBS, forming the DBS+ABT group. Seven PwPD without DBS were matched based on age, gender, and ambulation status, forming the ABT group. All 14 participants received ABT following the Lee Silverman Voice Therapy BIG protocol for 16 weeks. Outcome scores to assess functional leg strength, mobility, and balance were measured pre and post intervention. A repeated measures ANOVA was performed with pre to post as the within group factor and group assignment as the between group factor. Results: No significant interaction effects were found. Significant main effects of time were found for mobility and strength outcomes. Both groups improved from pre to post, but groups did not differ. Conclusions: The findings of this study indicate that ABT may be an effective intervention to improve functional leg strength, mobility, and balance for both PwPD with and without DBS.
Abstract	Background and Introduction: As the prevalence of Parkinson’s disease (PD) increases, novel treatment methods are sought to slow the disease progression. Because medication loses effectiveness with prolonged use, deep brain stimulation (DBS) can become a surgical option. There are positive outcomes with the use of amplitude-based training (ABT) as treatment for persons with PD (PwPD), but little research has been done to support its effectiveness for individuals with DBS. Purpose: The purpose of this retrospective case series is to investigate the effects of ABT on people with and without DBS. We hypothesize that ABT will produce improvements on mobility outcomes in PwPD regardless of DBS status. Methods: Data was collected from 7 PwPD with DBS, forming the DBS+ABT group. Seven PwPD without DBS were matched based on age, gender, and ambulation status, forming the ABT group. All 14 participants received ABT following the Lee Silverman Voice Therapy BIG protocol for 16 weeks. Outcome scores to assess functional leg strength, mobility, and balance were measured pre and post intervention. A repeated measures ANOVA was performed with pre to post as the within group factor and group assignment as the between group factor. Results: No significant interaction effects were found. Significant main effects of time were found for mobility and strength outcomes. Both groups improved from pre to post, but groups did not differ. Conclusions: The findings of this study indicate that ABT may be an effective intervention to improve functional leg strength, mobility, and balance for both PwPD with and without DBS.
关键词	LSVT; falls; progressive disease; matched-control; strength; balance; physical therapy
KeyWord	LSVT; falls; progressive disease; matched-control; strength; balance; physical therapy
基金项目
页码	-

参考文献
相关文献

1.Noyce AJ, Bestwick JP, Silveira-Moriyama L, Hawkes CH, Giovannoni G, Lees AJ, et al. Meta-analysis of early nonmotor features and risk factors for Parkinson disease. Ann Neurol. 2012;72(6):893–901.

2.Pringsheim T, Jette N, Frolkis A, Steeves TDL. The prevalence of Parkinson’s disease: A systematic review and meta-analysis. Mov Disord. 2014;29(13):1583–90.

3.Marras C, Beck JC, Bower JH, Roberts E, Ritz B, Ross GW, et al. Prevalence of Parkinson’s disease across North America. NPJ Parkinsons Dis. 2018;4(1):21.

4.Nemade D, Subramanian T, Shivkumar V. An Update on Medical and Surgical Treatments of Parkinson’s Disease. Aging Dis. 2021;12(4):1021.

5.Dickson DW. Neuropathology of Parkinson disease. Parkinsonism Relat Disord. 2018;46(1):S30–3.

6.Jankovic J. Parkinson’s disease: Clinical Features and Diagnosis. J Neurol Neurosurg Psychiatry. 2008;79(4):368–76.

7.Tysnes OB, Storstein A. Epidemiology of Parkinson’s Disease. J Neural Transm. 2017;124(8):901–5.

8.Levin J, Kurz A, Arzberger T, Giese A, Höglinger GU. The Differential Diagnosis and Treatment of Atypical Parkinsonism. Dtsch Arztebl Int. 2016;113(5):61–9.

9.Afentou N, Jarl J, Gerdtham U, Saha S. Economic Evaluation of Interventions in Parkinson’s Disease: A Systematic Literature Review. Mov Disord Clin Pract. 2019;6(4):282–90.

10.Gandhi KR, Abdolreza Saadabadi. Levodopa (L-Dopa)
[Internet]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK482140/. Accessed on 13 Nov 2024.

11.Fox SH, Katzenschlager R, Lim SY, Barton B, de Bie RMA, Seppi K, et al. International Parkinson and Movement Disorder Society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson’s disease. Mov Disord. 2018;33(8):1248–66.

12.McDonnell MN, Rischbieth B, Schammer TT, Seaforth C, Shaw AJ, Phillips AC. Lee Silverman Voice Treatment (LSVT)-BIG to improve motor function in people with Parkinson’s disease: a systematic review and meta-analysis. Clin Rehabil. 2018;32(5):607–18.

13.Spielman J, Mahler L, Halpern A, Gilley P, Klepitskaya O, Ramig L. Intensive voice treatment (LSVT®LOUD) for Parkinson’s disease following deep brain stimulation of the subthalamic nucleus. J Commun Disord. 2011;44(6):688–700.

14.Tripoliti E, Strong L, Hickey F, Foltynie T, Zrinzo L, Candelario J, et al. Treatment of dysarthria following subthalamic nucleus deep brain stimulation for Parkinson’s disease. Mov Disord. 2011;26(13):2434–6.

15.Artusi CA, Rinaldi D, Balestrino R, Lopiano L. Deep brain stimulation for atypical parkinsonism: A systematic review on efficacy and safety. Parkinsonism Relat Disord. 2022;96:109–18.

16.Powell LE, Myers AM. The Activities-specific Balance Confidence (ABC) Scale. J Gerontol A Biol Sci Med Sci. 1995;50(1):M28-M34.

17.Mak MK, Pang MY. Fear of falling is independently associated with recurrent falls in patients with Parkinson’s disease: a 1-year prospective study. J Neurol. 2009;256:1689-1695.

18.Parkinson EDGE Task Force Recommendations. Available from: https://www.neuropt.org/docs/default-source/edge-updates-november-2021/disease-stage-rating-final.pdf?sfvrsn=16f95f43_2. Accessed on 13 Nov 2024.

19.Schepens S, Goldberg A, Wallace M. The short version of the Activities-specific Balance Confidence (ABC) scale: its validity, reliability, and relationship to balance impairment and falls in older adults. Arch Gerontol Geriatr. 2010;51(1):9-12.

20.Zhang D, Tian F, Gao W, et al. The Chinese short version of the Activities-specific Balance Confidence Scale: its validity, reliability, and predictive value for future falls in community-dwelling older adults. Clin Interv Aging. 2022;17:1483-1491.

21.Duncan RP, Leddy AL, Earhart GM. Five Times Sit-to-Stand Test Performance in Parkinson’s Disease. Arch Phys Med Rehabil. 2011;92(9):1431–6.

22.Nocera JR, Stegemöller EL, Malaty IA, Okun MS, Marsiske M, Hass CJ. Using the Timed Up & Go Test in a Clinical Setting to Predict Falling in Parkinson’s Disease. Arch Phys Med Rehabil. 2013;94(7):1300–5.

23.Ekmekyapar Fırat Y, Turgay T, Soğan SS, Günel Karadeniz P. Effects of LSVT-BIG via telerehabilitation on non-motor and motor symptoms and quality of life in Parkinson’s disease. Acta Neurol Belg. 2023;123(1):207–14.

24.Castrioto A, Volkmann J, Krack P. Postoperative management of deep brain stimulation in Parkinson’s disease. Handb Clin Neurol. 2013;116:129–46.

25.Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. London (UK): Routledge; 1988.

26.Nordin E, Rosendahl E, Lundin-Olsson L. Timed “Up & Go” test: reliability in older people dependent in activities of daily living—focus on cognitive state. Phys Ther. 2006;86(5):646–55.

27.Jung IH, Chang KW, Park SH, Chang WS, Jung HH, Chang JW. Complications After Deep Brain Stimulation: A 21-Year Experience in 426 Patients. Front Aging Neurosci. 2022;14:819730.

28.Feng L, Liu Y, Tang H, Ling Z, Xu L, Yuan W, et al. Delayed Recovery After Deep Brain Stimulation Surgery for Parkinson’s Disease Under General Anesthesia-Cases Report. Front Surg. 2022;9:811337.

29.Peterka M, Odorfer T, Schwab M, Volkmann J, Zeller D. LSVT-BIG therapy in Parkinson’s disease: physiological evidence for proprioceptive recalibration. BMC Neurol. 2020;20:1–8.

30.Farley BG, Koshland GF. Training BIG to move faster: The application of the speed–amplitude relation as a rehabilitation strategy for people with Parkinson’s disease. Experimental Brain Research. 2005;167(3):462–7.

引用本文

Rosemary Lackey Babcock,Abigail Anderson,Laurie Neely*,Christina Speranza,Caitlyn Wilkerson,Jennifer Tolle,Kathleen Salik,Rolando Lazaro,Morris Casano Beato. The Effects of Amplitude-Based Training on Mobility, Functional Leg Strength, and Balance Confidence in Persons with Parkinson’s Disease with and Without Deep Brain Stimulation: A Case Series [J]. Advances in Geriatric Medicine and Research. 2025; 7; (2). - .

文献评论

相关学者

相关机构