| Abstract |
【Abstract】Objective To investigate the effect of catecholamine-mediated anti-anxiety depression drugs on serum catecholamine (CA) concentration and myocardial ischemia reperfusion injury (MIRI) in patients with acute myocardial infarction (AMI) without depressive disorder. Methods A total of 111 patients with AMI PCI without depressive disorder (MD) who were admitted from July 2018 to December 2020 were selected and randomly divided into two groups. 55 patients in the control group were given conventional AMI drug treatment, and 56 patients in the observation group were treated with conventional AMI. On the basis of drug treatment, clonazepam tablets and sertraline tablets were taken for drug intervention before and 6 hours after percutaneous coronary intervention (PCI), and the serum CA concentrations of the two groups were compared (before and after surgery). Adrenaline (AD), norepinephrine (NAD) and dopamine (DOP)), PCI (preoperative and postoperative neutrophil count to lymphocyte count ratio (NLR), mean platelet volume (MPV), serum amino group Terminal pro-brain natriuretic peptide (NT-proBNP) level), reperfusion arrhythmia (RA), sudden cardiac death. Results The AD, NAD and DOP of the two groups were lower than those before the operation, and the observation group was better than the control group (P<0.05). The indexes of NLR, MPV and NT-proBNP in the control group after operation were higher than those before the operation, and the indexes of the observation group were lower than those before operation, and the observation group was lower than the control group (P<0.05). The incidence of postoperative RA in the control group was 50.91%, the incidence of RA in the observation group was 19.64% (P<0.05), the incidence of sudden cardiac death in the control group was 5.45%, and the incidence in the observation group was 0.00% (P>0.05). Conclusion Catecholamine-mediated anti-anxiety and depressive drugs are satisfactory for patients with AMI without depressive disorder, increasing NLR, MPV, and NT-proBNP indexes, and reducing CA concentration, RA and the incidence of sudden cardiac death.
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