Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food-Immunometabolism-CSCIED科技核心评价数据库-手机版

Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food

Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food

ES评分 0 浏览量：1089 下载量：0

DOI	10.20900/immunometab20220011
刊名	Immunometabolism IJ
年，卷(期)	2022, 4(2)
作者	Filippi, Marie-Dominique,
作者单位	[Filippi, Marie-Dominique] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Res Fdn, Div Expt Hematol & Canc Biol,Dept Pediat, Cincinnati, OH 45229 USA
摘要	Hematopoietic stem cells (HSC) directly initiate a response to bacterial infections by rapidly entering the cell cycle in order to produce mature blood cells. An important issue in the field of HSC biology is to understand how metabolic activities of HSC are fueled during specific condition that require HSC activation. In their paper, Mistry et al. provide evidence that bacterial infections trigger an increased in free fatty acid uptake by HSC that fuel fatty acid oxidation and mitochondrial respiration activities. This increased fatty acid uptake is exclusively dependent on the upregulation of the fatty acid transporter CD36. This study shed important light into the metabolic needs of HSC during septic conditions.
Abstract	Hematopoietic stem cells (HSC) directly initiate a response to bacterial infections by rapidly entering the cell cycle in order to produce mature blood cells. An important issue in the field of HSC biology is to understand how metabolic activities of HSC are fueled during specific condition that require HSC activation. In their paper, Mistry et al. provide evidence that bacterial infections trigger an increased in free fatty acid uptake by HSC that fuel fatty acid oxidation and mitochondrial respiration activities. This increased fatty acid uptake is exclusively dependent on the upregulation of the fatty acid transporter CD36. This study shed important light into the metabolic needs of HSC during septic conditions.
关键词	hematopoietic stem cells; infection; fatty acid; CD36; mitochondria
KeyWord	hematopoietic stem cells; infection; fatty acid; CD36; mitochondria
基金项目
页码	1-5

参考文献
相关文献

1. Demerdash Y, Kain B, Essers MAG, King KY. Yin and Yang: The dual effects of interferons on hematopoiesis. Exp Hematol. 2021 Apr;96:1-12.
2. Filippi MD, Ghaffari S. Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities. Blood. 2019 May 2;133(18):1943-52.
3. Ito K, Suda T. Metabolic requirements for the maintenance of self-renewing stem cells. Nature reviews. Nat Rev Mol Cell Biol. 2014 Apr;15(4):243-56.
4. Ho TT, Warr MR, Adelman ER, Lansinger OM, Flach J, Verovskaya EV, et al. Autophagy maintains the metabolism and function of young and old stem cells. Nature. 2017 Mar 9;543(7644):205-10.
5. Liang R. Arif T, Kalmykova S, Kasianov A, Lin M, Menon V, et al. Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency. Cell Stem Cell. 2020 Mar 5;26(3):359-76.e7.
6. Schonberger K, Obier N, Romero-Mulero MC, Cauchy P, Mess J, Pavlovich PV, et al. Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity. Cell Stem Cell. 2022 Jan 6;29(1):131-48.e10.
7. Ito K, Turcotte R, Jinhua Cui J, Zimmerman SE, Pinho S, Mizoguchi T, et al. Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science. 2016 Dec 2;354(6316):1156-1160.
8. Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, et al. p38alpha Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress. Cell Stem Cell. 2016 Aug 4;19(2):192-204.
9. Qi L, Martin-Sandoval MS, Merchant S, Gu W, Eckhardt M, Mathews TP, et al. Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration. Cell Stem Cell. 2021 Nov 4;28(11):1982-99.e8.
10. Ito K, Ito, K. Hematopoietic stem cell fate through metabolic control. Exp Hematol. 2018 Aug;64:1-11.
11. Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, et al. A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med. 2012 Sep;18(9):1350-8.
12. Mistry JJ, Hellmich C, Moore JA, Jibril A, Macaulay I, Mar Moreno-Gonzalez M, et al. Free fatty-acid transport via CD36 drives beta-oxidation-mediated hematopoietic stem cell response to infection. Nat Commun. 2021 Dec 8;12(1):7130.
13. Ye H, Adane B, Khan N, Sullivan T, Minhajuddin M, Maura Gasparetto M, et al. Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche. Cell Stem Cell. 2016 Jul 7;19(1):23-37.
14. Shafat MS, Oellerich T, Mohr S, Robinson SD, Edwards DR, Marlein CR, et al. Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment. Blood. 2017 Mar 9;129(10):1320-32.
15. van-Charvet L, Pagler T, Gautier EL, Avagyan S, Siry RL, Han S, et al. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science. 2010 Jun 25;328(5986):1689-93.

引用本文

Filippi, Marie-Dominique. Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food [J]. Immunometabolism. 2022; 4; (2). 1 - 5.

文献评论

相关学者

相关机构