Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food-Immunometabolism-CSCIED科技核心评价数据库-手机版

Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food

Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food

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DOI	10.20900/immunometab20220011
刊名	Immunometabolism IJ
年，卷(期)	2022, 4(2)
作者	Filippi, Marie-Dominique,
作者单位	[Filippi, Marie-Dominique] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Res Fdn, Div Expt Hematol & Canc Biol,Dept Pediat, Cincinnati, OH 45229 USA
摘要	Hematopoietic stem cells (HSC) directly initiate a response to bacterial infections by rapidly entering the cell cycle in order to produce mature blood cells. An important issue in the field of HSC biology is to understand how metabolic activities of HSC are fueled during specific condition that require HSC activation. In their paper, Mistry et al. provide evidence that bacterial infections trigger an increased in free fatty acid uptake by HSC that fuel fatty acid oxidation and mitochondrial respiration activities. This increased fatty acid uptake is exclusively dependent on the upregulation of the fatty acid transporter CD36. This study shed important light into the metabolic needs of HSC during septic conditions.
Abstract	Hematopoietic stem cells (HSC) directly initiate a response to bacterial infections by rapidly entering the cell cycle in order to produce mature blood cells. An important issue in the field of HSC biology is to understand how metabolic activities of HSC are fueled during specific condition that require HSC activation. In their paper, Mistry et al. provide evidence that bacterial infections trigger an increased in free fatty acid uptake by HSC that fuel fatty acid oxidation and mitochondrial respiration activities. This increased fatty acid uptake is exclusively dependent on the upregulation of the fatty acid transporter CD36. This study shed important light into the metabolic needs of HSC during septic conditions.
关键词	hematopoietic stem cells; infection; fatty acid; CD36; mitochondria
KeyWord	hematopoietic stem cells; infection; fatty acid; CD36; mitochondria
基金项目
页码	1-5

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引用本文

Filippi, Marie-Dominique. Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food [J]. Immunometabolism. 2022; 4; (2). 1 - 5.

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