Journal of International Psychiatry

【Abstract】Objective To investigate the application of dexmedetomidine in modified electroconvulsive therapy (MECT) in patients with depression.Methods A total of 106 patients who needed to receive MECT in our hospital from August 2021 to August 2022 were prospectively selected and divided into observation group and control group by random number table method, 53 cases in each group. The observation group was injected with dexmedetomidine combined with propofol, and the control group was injected with the same amount of normal saline combined with propofol. Perioperative indexes, pre-operative and post-operative Self-rating Depression Scale (SDS), preoperative and postoperative hemodynamics [heart rate (HR)] and mean arterial pressure (mean arterial pressure) of both groups were recorded. MAP), pulse oxygen saturation (SpO2)] and the occurrence of adverse reactions in the two groups.Results The dosage of propofol in the observation group was significantly lower than that in the control group (P < 0.05). After operation, SDS scores of both groups were decreased (P < 0.05), and the observation group was significantly lower than the control group (P < 0.05). HR and MAP of the two groups were significantly changed after surgery (P < 0.05), and HR and MAP of the observation group were significantly lower than those of the control group (P < 0.05).The incidence of postoperative agitation, injection pain and respiratory depression in the observation group was significantly lower than that in the control group (P < 0.05). Conclusion Dexmedetomidine combined with propofol in MECT can reduces depression, and the intraoperative hemodynamic stability is more stable, while reducing the occurrence of adverse reactions.

【Key words】Mental disorder; Modified electroconvulsive therapy; Dexmedetomidine; Propofol; Hemodynamics