| Abstract |
[Objective] To investigate and analyze the relationship between clinical symptoms and inflammatory factors in first-episode unmedicated schizophrenia.[Methods] Seventy-six participants were recruited and divided into a study group (patients with first-episode unmedicated schizophrenia) and a control group (healthy population) based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) diagnostic criteria. Serum PIGF, VEGF-D, bFGF, IFN-γ, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, VEGF, Eotaxin, IP-10, and MCP-1 levels were measured in all individuals using ultrasensitive electrochemiluminescence analysis (MSD); and relevant patient data, including sociodemographic data, were also collected, Positive And Negative Symptom Scale (PANSS), Brief Psychiatric Rating Scale (BPRS) and its subscales.[Results] The levels of IL-1β, IL-4, bFGF, IL-13, IL-8, IP-10 and MCP-1 were significantly higher (P<0.05) and the levels of VEGF-D were lower (P<0.05) in the study group compared to healthy controls. While IL-2, Eotaxin, PIGF, IFN-γ, IL-6 and VEGF showed no significant difference between the two groups (P>0.05). IL-1β was positively correlated with the positive factor in the PANSS scale (r=0.346, P=0.029); and negatively correlated with the anxiety-depression factor in the PANSS scale (r=-0.339, P=0.033). positively correlated with both the BPRS scale total score and the hostile suspicion factor (r=0.384, P=0.015; r=0.365, P=0.02, respectively). the MCP-1 was negatively correlated with the excitability factor of the PANSS scale (r=-0.314, P=0.049). the IL-13 was negatively correlated with the excitement factor of the PANSS scale (r=-0.326, P=0.04), and with the anxiety and depression factor of the PANSS scale (r=-0.339, P=0.033). P=0.04) and negatively correlated with the thinking disorder factor in the BPRS scale (r=-0.34, P=0.032). By ROC curve analysis, the results were IL-1β (AUCROC: 0.8361, sensitivity: 85%, specificity: 97.22%). IL-4 (AUCROC: 0.8469, sensitivity: 80%, specificity: 97.22%). bFGF (AUCROC: 0.9944, sensitivity: 95%, specificity: 97.22%) . IL-8 (AUCROC: 0.8479, sensitivity: 90%, specificity: 75%).[Conclusion] Serum IL-1β, IL-4, bFGF, IL-13, IL-8, IP-10, MCP-1 and VEGF-D levels differed between patients with first-episode medication-naïve schizophrenia and the healthy population; serum IL-1β, IL-13 and serum MCP-1 levels correlated with some clinical symptoms; serum IL-1β, IL-4, bFGF and IL-8 levels were of high value in the diagnosis of first-episode medication-naïve schizophrenia.
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