Journal of International Psychiatry

[Abstract]：Objective To study the europsychiatric symptoms of patients with chronic renal failure after treatment with cephalosporin antibiotic, and to explore the correlation. Methods Between November 2011 Month and November 2015, a total of 56 patients with chronic renal failure complicated by infection come to our hospital for treatment. According to different antibiotics use, they were divided into the cephalosporin group (24cases) and non-cephalosporin group (17 cases). To compare the incidence of neuropsychiatric symptoms and EPRS scores before and after treatment for two groups, and to study neuropsychiatric symptoms after using different cephalosporins. Results The overall incidence of neuropsychiatric symptoms for cephalosporin group and non-cephalosporin group were52.38% and 29.41% respectively, the incidence of neuropsychiatric symptoms cephalosporin group was significantly higher than the non-cephalosporin group, the difference was significant (P <0.05); After the use of antibiotics, EPRS score for two groups significantly increased, and significant non-cephalosporin group, the difference was higher than the cephalosporin group were statistically significant (P <0.05);After using of three cephalosporins including cephradine, cefepime and cefoperazone, the incidence of neuropsychiatric symptoms was no significant difference (P> 0.05).Conclusion Infected patients with chronic renal failure in the use of cephalosporins will greatly enhance the incidence of neuropsychiatric symptoms, therefore, should be combined in the treatment of the patients condition, the use of antibiotics for real-time adjustment to reduce neuropsychiatric symptoms.

[Keywords]: Cephalosporins; Chronic renal failure; Neuropsychiatric symptoms