Journal of International Psychiatry

ABSTRACT Objective: To study the variation of α-Syn protein in patients with schizophrenia before and after treatment and evaluate the prognostic value of α-Syn protein in schizophrenia. Methods: The contents of α-Syn protein in serum of 122 cases of schizophrenia and 60 cases of healthy controls were measured by a double-antibody sandwich ELISA. Results: The serum level of α-Syn protein in patients with schizophrenia was markedly decreased when compared to that of healthy control. The serum level of α-Syn protein of untreated patients was significantly lower than that of patients after treatment. Before treatment, the serum level of α-Syn protein was lower in patients with first episode psychosis than in those recurrence ensued. The concentration of α-Syn protein level in serum was positively related to the total PANSS(r=0.269,p=0.043), which suggested that the severer mental symptoms, the lower α-Syn protein level in serum. Conclusion: The measurement of α-Syn protein level could be used to diagnose mild brain injury of schizophrenia, estimate the extent of brain injury and the effect of treatments and judge prognosis,So it can be used as judgment early new indicator of schizophrenia mild brain injury.

KEY WORDS α-Syn protein; Schizophrenia; ELISA