Journal of International Psychiatry

【Abstract】 objectiveTo explore the efficacy of mirtazapine combined with conventional medicine in patients with chronic heart failure and depression.Method120 elderly patients with chronic heart failure and depression in our hospital from January 2014 to April 2015 were randomly divided into mirtazapine group and control group. Patients in control group were treated by conventional drug therapy for chronic heart failure while patients inmirtazapine groupwere treated bymirtazapine combined with conventional medicine. Hamilton Depression Scale score and cardiac function of patients in two groups before and after treatment were compared.ResultCompared to patientsbeforetreatment, patients inmirtazapine group and control group had lower Hamilton Depression Scale score 30, 90, 180, 300 days after treatment. Compared tocontrol group, patients in mirtazapine grouphad lower Hamilton Depression Scale score and higher score difference rate (p<0.05). Compared to patients before treatment, patients in mirtazapine group and control group had higher left ventricular ejection fraction and left ventricular fractional shortening, longer 6min walking test and slower heart rate (p<0.05). Compared to control group, patients in mirtazapine grouphadhigher left ventricular ejection fraction and left ventricular fractional shortening, longer 6min walking test and slower heart rate (p<0.05).Conclusion The efficacy of mirtazapine combined with conventional medicine in patients with chronic heart failure and depression is good and it can be widely used.

【Key word】Mirtazapine；Chronic heart failure；Depression；heart function；Hamilton Depression Scale score