Journal of International Psychiatry

Objective To observe the the effect and safety of donepezil HCL combining with Ginkgo Biloba Extractin treatment of elderly cognitive dysfunction. Methods 80 cases of cognitive dysfunction in elderly patients wererandomly divided into treatment group and control group，40 cases in the control group were given donepezil HCL，each time 5～10 mg，1 times a day，oral. On the basis of control group and treatment group with ginkgo biloba extractoral，40 mg per day，2 times a day，two groups were treated for six months. Before and after treatment，using MMSEscale，MoCA and ADL scale to evaluate all the patient. Results Before and after treatment，the MMSE scale score，MoCA scores in two groups of patients were significantly higher，and the comparison between the two groups have significantdifference，statistically significant（P<0.05）. before and after treatment，ADL scores in both groups weresignificantly lower，and the comparison between the two groups have significant difference，statistically significant（P<0.05）. Two groups of patients with the clinical efficacy of comparison，the difference was statistically significant（P<0.05）. Conclusion Donepezil HCL with ginkgo biloba extract therapy clinical curative effect of elderly cognitivedysfunction is better than that of donepezil HCL to medicine alone，is a kind of safety and effective treatment of agerelatedcognitive dysfunction clinical method

Donepezil HCL；Ginkgo Biloba Extract；Elderly Cognitive Dysfunction；Clinical Effectiveness