Journal of International Psychiatry

〇bjective To explore the efficacy and safety of venlafaxine combined with quetiapine or olanzap-in in treatment-resistant depression(TRD). Methods 80 patients with TRD were randomly divided into two com- bined groups, venlafaxine with quetiapine and venlafaxine with olanzapine, for8 weeks. Hamilton Rating Scale for Depression(HAMD) was used to evaluate the clinical e価cacy, at the same time recorded the adverse reactions. Results The response rate was67. 5% in quetiapine group and65% in olanzapin group. Both of two groups showed remarkable emcacy, and there was no significant difference between the two groups(Z2=0.05, P>0.05). In both of groups, the scores of 2nd, 4th, 6th, 8th weeks o「 HAMD were significantly reduced from the baseline and the difference was statistically significant(P<0.01). In olanzapin group, appetite and body weight gain were more ap- parent than the quetiapine group. There was significant difference between the two groups(X2=6. 27, P=0.01; K2 =4.58, P=0.03). Conclusion Venlafaxine combined with quetiapine or olanzapin are both good efficacy andwork fast in TRD. Venlafaxine combined with quetiapine doesless effect on appetite and body weight.

Treatment-resistant depression; Venlafaxine; Quetiapine; 01anzapin