Journal of International Psychiatry

〇bjective This study was to explore Yi quetiapine to treat bipolar mood disorder acute manic ep-isodes clinical efficacy and safety. Methods The author selected department92 cases diagnosed bipolar disorder patients with acute manic episodes according to the order of admission into quetiapine group and46 cases each I,ithi_ urn carbonate group, patients were treated for6 consecutive weeks, the two groups of patients in clinical treatment and differences in the incidence of adverse reactions. Results After three weeks of treatment, the first six weeks of quetiapine group mania score(18.5±3. 6) points, (11. 5±2.4) scores were significantly1ower than Lithium car- bonate group(21.6±3.9) points, (14.3±3.0) min(P<0.05). After three weeks of treatment, Lhe first six weeks of quetiapine manic score reduction rate(24. 18±8. 17)%, (52.87±21.64)% were significantly higher than Lithium carbonate group(13. 60±7. 03)%, (42. 80±19. 33)% (P<0. 05). After treatment markedly effec- tive rate (69.57%) first six weeks quetiapine group were significantly higher than Lithium carbonate group (91.30%) (P<0.05). Adverse reaction rates(10.87%) was significantlylower than Lithium carbonate group (28.26%) (P<0.05) quetiapine group. Conclusion Quetiapine to treat bipolar mood disorder acute manic epi-sodes exact clinical effect, lower incidence of adverse reactions.

Quetiapine; Bipolar disorder; Acute manic episodes; Clinical results; Safety