难治性抑郁症患者无抽搐电休克治疗前后血清BDNF水平的动态观察-国际精神病学杂志-CSCIED科技核心评价数据库-手机版

难治性抑郁症患者无抽搐电休克治疗前后血清BDNF水平的动态观察

The Effect of Modified Electroconvulsive Therapy on Serum Brain-Derived Neurotrophic Factor ofPatients with Treatment-Resistant Depression.

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DOI
刊名	国际精神病学杂志 Journal of International Psychiatry
年，卷(期)	2016, 43(2)
作者	黄兴兵*,黄　雄,何红波,孙　彬,梅　芳,张春平,
作者单位	广州市脑科医院 ;
摘要	目的　探讨无抽搐电休克治疗（MECT）对难治性抑郁症（TRD）患者血清脑源性神经营养因子（BDNF）水平的影响。方法　收集符合条件的TRD患者共60例，MECT前和第2、4、8次MECT后检测血清BDNF浓度，汉密尔顿抑郁量表（HAMD-17）评估。结果　（1）病例组第2、4、8次MECT后HAMD-17评分均明显低于MECT前（P <0.05）；（2）病例组治疗前BDNF水平、治疗前与第8次治疗后BDNF变化值在性别、精神病与非精神病性抑郁、缓解与未缓解方面比较均无显著性差异（P >0.05）；第8次MECT后BDNF水平在性别、精神病与非精神病性抑郁方面比较均无显著性差异（P >0.05），但在缓解与未缓解方面比较存在显著性差异（P <0.05）。（3）第8次MECT后HAMD评分与BDNF水平显著负相关（P <0.05）。结论　BDNF可能是TRD患者MECT疗效是否缓解的生物学指标。
Abstract	Abstract】Objective To explore the effect of modified electroconvulsive therapy（MECT）onserumbrain-de- （MECT）onserumbrain-de- MECT）onserumbrain-de- ）onserumbrain-de- on serum brain-de-rived neurotrophic factor（BDNF）ofpatientswithtreatment-resistantdepression（TRD）. （BDNF）ofpatientswithtreatment-resistantdepression（TRD）. BDNF）ofpatientswithtreatment-resistantdepression（TRD）. ）ofpatientswithtreatment-resistantdepression（TRD）. of patients with treatment-resistant depression（TRD）. （TRD）. TRD）. ）. Methods Sixty patients withTRD were included in the trial to receive a single standard 8 times MECT. The HAMD-17 were valuated before MECTand after the completion of the second，fourthandeighthMECTsessions. Bloodwasdrawnat thesametimeandserum ，fourthandeighthMECTsessions. Bloodwasdrawnat thesametimeandserum fourth and eighth MECT sessions. Blood was drawn at the same time and serumlevels of BDNF were examined with enzyme-linked immuno sorbent assay（ELISA）. （ELISA）. ELISA）. ）. Results （1）ScoresofHAMD-17 1）ScoresofHAMD-17 ）ScoresofHAMD-17 Scores of HAMD-17after the completion of the second，fourthandeightyMECTsessionswerelowercomparedwithpre-treatment（，fourthandeightyMECTsessionswerelowercomparedwithpre-treatment（ fourth and eighty MECT sessions were lower compared with pre-treatment（P <0.05）. ）.（2）Therewasmainlynocleardifferenceamongthesex，psychoticfeatures，remissionandBDNFlevels（ 2）Therewasmainlynocleardifferenceamongthesex，psychoticfeatures，remissionandBDNFlevels（）Therewasmainlynocleardifferenceamongthesex，psychoticfeatures，remissionandBDNFlevels（ There was mainly no clear difference among the sex，psychoticfeatures，remissionandBDNFlevels（，psychoticfeatures，remissionandBDNFlevels（ psychotic features，remissionandBDNFlevels（，remissionandBDNFlevels（ remission and BDNF levels（P >0.05）. ）.But there was significant difference among remission and BDNF levels after the completion of the eighth MECT sessions（P <0.05）.（3）TherewereclearnegativecorrelationsbetweenHAMDscoresandBDNFlevelsafterthecompletionof ）.（3）TherewereclearnegativecorrelationsbetweenHAMDscoresandBDNFlevelsafterthecompletionof .（3）TherewereclearnegativecorrelationsbetweenHAMDscoresandBDNFlevelsafterthecompletionof （3）TherewereclearnegativecorrelationsbetweenHAMDscoresandBDNFlevelsafterthecompletionof 3）TherewereclearnegativecorrelationsbetweenHAMDscoresandBDNFlevelsafterthecompletionof ）TherewereclearnegativecorrelationsbetweenHAMDscoresandBDNFlevelsafterthecompletionof There were clear negative correlations between HAMD scores and BDNF levels after the completion ofthe eighth MECT sessions（P <0.05）. Conclusions Theresultssuggestedthat serumBDNFlevelsmight becomeape- ）. Conclusions Theresultssuggestedthat serumBDNFlevelsmight becomeape- . Conclusions The results suggested that serum BDNF levels might become a pe-ripheral biomarker relevant to remission of TRD patients after MECT.
关键词	无抽搐电休克；难治性抑郁症；脑源性神经营养因子
KeyWord	Modified electroconvulsive therapy；Treatment-resistantdepression；Brain-derivedneurotrophicfactor
基金项目
页码	236-238

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黄兴兵*,黄　雄,何红波,孙　彬,梅　芳,张春平. 难治性抑郁症患者无抽搐电休克治疗前后血清BDNF水平的动态观察 [J]. 国际精神病学杂志. 2016; 43; (2). 236 - 238.

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