Journal of International Psychiatry

Abstract】Objective To investigate the effect of folic acid on depressive symptoms in patients with vasculardepression. Methods 108 patients with vascular depression were randomly divided into treatment group and controlgroup，ThecontrolgroupwastreatedwithEscitalopramOxalateTablets10mgAmtreatment，accordingtothecondition ，ThecontrolgroupwastreatedwithEscitalopramOxalateTablets10mgAmtreatment，accordingtothecondition The control group was treated with Escitalopram Oxalate Tablets 10mg Am treatment，accordingtothecondition ，accordingtothecondition according to the conditionof tolerance added amount to 20 mg Am treatment within a week，Onthisbasis，thetreatment groupwastreatedwith ，Onthisbasis，thetreatment groupwastreatedwith On this basis，thetreatment groupwastreatedwith ，thetreatment groupwastreatedwith the treatment group was treated withfolic acid tablets Bid 10mg. Results There was no significant difference in Hcy level and HAMD score between the twogroups before treatment，andthereweresignificant differencesafter2monthsof treatment. ，andthereweresignificant differencesafter2monthsof treatment. and there were significant differences after 2 months of treatment. Conclusion For patientswith vascular depression，folicacidcanimprovetheantidepressioneffect. ，folicacidcanimprovetheantidepressioneffect. folic acid can improve the anti depression effect.

Vascular depression；homocysteine（Hcy）；Hamiltondepressionratingscale（HAMD）；Folicacid.