张永东*,段　妮,王立涛,刘彩兴,

Objective To investigate the effect of repetitive transcranial magnetic stimulation（rTMS）onintrac- （rTMS）onintrac- rTMS）onintrac- ）onintrac- on intrac-table insomnia. Methods Sixty patients with intractable insomnia were randomly divided into rTMS group and controlgroup，withthirtypatientsineachgroup. PatientsintherTMSgroupweretreatedwithrTMSplusoral administration ，withthirtypatientsineachgroup. PatientsintherTMSgroupweretreatedwithrTMSplusoral administration with thirty patients in each group. Patients in the rTMS group were treated with rTMS plus oral administrationof benzodiazepines drugs，whilepatientsinthecontrol groupreceivedshamrTMSplusoral administrationof benzodi- ，whilepatientsinthecontrol groupreceivedshamrTMSplusoral administrationof benzodi- while patients in the control group received sham rTMS plus oral administration of benzodi-azepines drugs，fortwentyminuteseachtime，onceaday，totallyforfourweeks. ThePittsburghsleepqualityindex ，fortwentyminuteseachtime，onceaday，totallyforfourweeks. ThePittsburghsleepqualityindex for twenty minutes each time，onceaday，totallyforfourweeks. ThePittsburghsleepqualityindex ，onceaday，totallyforfourweeks. ThePittsburghsleepqualityindex once a day，totallyforfourweeks. ThePittsburghsleepqualityindex ，totallyforfourweeks. ThePittsburghsleepqualityindex totally for four weeks. The Pittsburgh sleep quality indexquestionnaire，sleeplatency，numberofawakeningandawakeningtimeonpolysomnographywereevaluatedandcom- ，sleeplatency，numberofawakeningandawakeningtimeonpolysomnographywereevaluatedandcom- sleep latency，numberofawakeningandawakeningtimeonpolysomnographywereevaluatedandcom- ，numberofawakeningandawakeningtimeonpolysomnographywereevaluatedandcom- number of awakening and awakening time on polysomnography were evaluated and com-pared the clinical efficacy before and after four weeks treatment between two groups. Results Pittsburgh sleep qualityindex was significantly lower，andthesleeplatency，numberof awakeningandawakeningtimeonpolysomnography ，andthesleeplatency，numberof awakeningandawakeningtimeonpolysomnography and the sleep latency，numberof awakeningandawakeningtimeonpolysomnography ，numberof awakeningandawakeningtimeonpolysomnography number of awakening and awakening time on polysomnographywere significantly shorter after rTMS treatment than those before treatment and those in the control group（P < 0.01）. ）.Conclusion rTMS can significantly shorten the sleep latency time，numberof awakeningandawakeningtimeinthe ，numberof awakeningandawakeningtimeinthe number of awakening and awakening time in thepatients with intractable insomnia. It is reliable and effective for rTMS to treat intractable insomnia.

重复经颅磁刺激；顽固性失眠；苯二氮卓类药物