Journal of International Psychiatry

Objective To investigate the clinical effect of Donepezil in the treatment of for early alzheimer’sdisease complicated with high homocysteine. Methods 80 cases of early alzheimer’s disease complicated with highhomocysteine who got medical treatment in our hospital form January 2012 to March 2015 were randomly divided intotwo groups，eachgrouphad40patients，patientsincontrol groupweretreatedwithoral folicacid，vitaminB ，eachgrouphad40patients，patientsincontrol groupweretreatedwithoral folicacid，vitaminB each group had 40 patients，patientsincontrol groupweretreatedwithoral folicacid，vitaminB ，patientsincontrol groupweretreatedwithoral folicacid，vitaminB patients in control group were treated with oral folic acid，vitaminB ，vitaminB vitamin B12 tabletsand memantine hydrochloride tablets，whilethoseinresearchgroupwereaddedwithDonepezil onthebasisof control ，whilethoseinresearchgroupwereaddedwithDonepezil onthebasisof control while those in research group were added with Donepezil on the basis of controlgroup，all of thosepatientswerefollowed-upwith3months，thentheMMSEandADLscoreandadversereactions ，all of thosepatientswerefollowed-upwith3months，thentheMMSEandADLscoreandadversereactions all of those patients were followed-up with 3 months，thentheMMSEandADLscoreandadversereactions ，thentheMMSEandADLscoreandadversereactions then the MMSE and ADL score and adverse reactionsduring the course of the treatment were compared. Results After treatment，theMMSEscoreandADLscoreofresearch ，theMMSEscoreandADLscoreofresearch the MMSE score and ADL score of researchgroup were higher than that of control group（P <0.05），thedifferencesreachedstatistical level，theproportionof ），thedifferencesreachedstatistical level，theproportionof the differences reached statistical level，theproportionof ，theproportionof the proportion ofinsomnia，dizziness，nausea，diarrheaanduroclepsiaof thetwogroupshadnon-statisticallydifferences（ ，dizziness，nausea，diarrheaanduroclepsiaof thetwogroupshadnon-statisticallydifferences（ dizziness，nausea，diarrheaanduroclepsiaof thetwogroupshadnon-statisticallydifferences（ ，nausea，diarrheaanduroclepsiaof thetwogroupshadnon-statisticallydifferences（ nausea，diarrheaanduroclepsiaof thetwogroupshadnon-statisticallydifferences（ ，diarrheaanduroclepsiaof thetwogroupshadnon-statisticallydifferences（ diarrhea and uroclepsia of the two groups had non- statistically differences（P >0.05）， ），after treatment，thehomocysteineconcentrationsofresearchgroupwasconsiderablylowerthancontrolgroup（ ，thehomocysteineconcentrationsofresearchgroupwasconsiderablylowerthancontrolgroup（ the homocysteine concentrations of research group was considerably lower than control group（P <0.05）. ）.Conclusion The application of Donepezil in the treatment of early alzheimer’s disease complicated with high homo-cysteine would contribute to enhancing the clinical effect of the treatment，reducingserumhomocysteinecontentsand ，reducingserumhomocysteinecontentsand reducing serum homocysteine contents andimproving patients cognitive function and activities of daily living.

Donepezil；HighHomocysteine；EarlyAlzheimersDisease ；HighHomocysteine；EarlyAlzheimersDisease High Homocysteine；EarlyAlzheimersDisease ；EarlyAlzheimersDisease Early Alzheimers Disease