Journal of International Psychiatry

Objective To compare the different of safety in the treatment of first-episode schizophrenia betweenamisulpride and olanzapine. Methods A retrospective study was conducted 80 cases with first-episode schizophreniatreatment of amisulpride or olanzapine on the general demographic data、sidereaction、evaluationofpsychiatricsymptoms 、sidereaction、evaluationofpsychiatricsymptoms side reaction、evaluationofpsychiatricsymptoms 、evaluationofpsychiatricsymptoms evaluation of psychiatric symptomsand laboratory examination．Results All of 80 cases，Thenumberof abnormal sexhormoneswas25caseinamisulpride ，Thenumberof abnormal sexhormoneswas25caseinamisulpride The number of abnormal sex hormones was 25 case in amisulpridegroup，andwas18caseinolanzapinegroup．Thedifferencebetweentwogroupshavestatisticallysignificant（χ ，andwas18caseinolanzapinegroup．Thedifferencebetweentwogroupshavestatisticallysignificant（χ and was 18 case in olanzapine group．Thedifferencebetweentwogroupshavestatisticallysignificant（χ ．Thedifferencebetweentwogroupshavestatisticallysignificant（χ The difference between two groups have statistically significant（χ （χ2=4.220，P =0.40）. Further studiesconclusivelyshowedamisulpridegrouphadhigher level of serumPRLthanolanzapine ）. Further studiesconclusivelyshowedamisulpridegrouphadhigher level of serumPRLthanolanzapine Further studies conclusively showed amisulpride group had higher level of serum PRL than olanzapinegroup［（63.12±38.74）ng/ml；（37.84±36.50）ng/ml］（ ［（63.12±38.74）ng/ml；（37.84±36.50）ng/ml］（ 63.12±38.74）ng/ml；（37.84±36.50）ng/ml］（ ）ng/ml；（37.84±36.50）ng/ml］（ ng/ml；（37.84±36.50）ng/ml］（ ；（37.84±36.50）ng/ml］（ 37.84±36.50）ng/ml］（ ）ng/ml］（ ng/ml］（ ］（t =-3.003，P =0.004）. Thedifferenceof thegeneral demo- ）. Thedifferenceof thegeneral demo- The difference of the general demo-graphic data、sidereaction、evaluationof psychiatricsymptomsbetweenmisulpridegroupandolanzapinegroupwerenot 、sidereaction、evaluationof psychiatricsymptomsbetweenmisulpridegroupandolanzapinegroupwerenot side reaction、evaluationof psychiatricsymptomsbetweenmisulpridegroupandolanzapinegroupwerenot 、evaluationof psychiatricsymptomsbetweenmisulpridegroupandolanzapinegroupwerenot evaluation of psychiatric symptoms between misulpride group and olanzapine group were notsignificant（P >0.05）. ）. Conclusion The safety of amisulpride on first-episode schizophrenia is equivalent with olanzapine.We should pay attention to the influence of endocrine of the amisulpride therapy schizophrenia patients.【Keywords】 Key words】Amisulpride；Olanzapine；Schizophrenia； ；Olanzapine；Schizophrenia； Olanzapine；Schizophrenia； ；Schizophrenia； Schizophrenia；

Amisulpride；Olanzapine；Schizophrenia； ；