Journal of International Psychiatry

Objective To explore the clinical perspectives of Venlafaxine in the treatment of chronic obstructivepulmonary disease with anxiety and depression. Methods 86 cases of COPD complicated with anxiety and depressionpatients from January 2012 to December 2013 in our hospital，andtheywererandomlydividedintocontrol groupand ，andtheywererandomlydividedintocontrol groupand and they were randomly divided into control group andexperimental group. The control group received routine treatment，experimental groupreceivedvenlafaxineontheba- ，experimental groupreceivedvenlafaxineontheba- experimental group received venlafaxine on the ba-sis of routine treatment，after4weeks treatment，comparedthepulmonaryfunction，lifequality，negativeemotion ，after4weeks treatment，comparedthepulmonaryfunction，lifequality，negativeemotion after 4 weeks treatment，comparedthepulmonaryfunction，lifequality，negativeemotion ，comparedthepulmonaryfunction，lifequality，negativeemotion compared the pulmonary function，lifequality，negativeemotion ，lifequality，negativeemotion life quality，negativeemotion ，negativeemotion negative emotionand adverse effects of these two. Results After 4 weeks’ treatment，theFEV1andFEV1/FVCof experimental group ，theFEV1andFEV1/FVCof experimental group the FEV1 and FEV1 /FVC of experimental groupwere significantly higher than control group，SGRQ，HAMAandHAMDscoresweremarkedlylowerthancontrolgroup ，SGRQ，HAMAandHAMDscoresweremarkedlylowerthancontrolgroup SGRQ，HAMAandHAMDscoresweremarkedlylowerthancontrolgroup ，HAMAandHAMDscoresweremarkedlylowerthancontrolgroup HAMA and HAMD scores were markedly lower than control group（P <0.01），andnostatisticaldifferenceinadverseeffectratebetweenthesetwogroups（ ），andnostatisticaldifferenceinadverseeffectratebetweenthesetwogroups（ and no statistical difference in adverse effect rate between these two groups（P >0.05）. ）. Conclusion Ven-lafaxine could improve anxiety and depressive symptoms of patients with COPD，andimprovetheirlifequality，there- ，andimprovetheirlifequality，there- and improve their life quality，there- ，there- there-fore it was suitable for clinical promotion.

Venlafaxine；Chronicobstructivepulmonarydisease；Anxiety；Depression.