Journal of International Psychiatry

Objective　To compare the efficacy and adverse effect respectively of Amisulpride or Aripiprazole inthe treatment of female patients with schizophrenia．Methods　80 female patients with schizophrenia which were treat-ed in our hospital during January 2013to December 2014 were selected，and then were randomly divided into Amisul-pride group or Aripiprzole group，each group of 40 patients were treated withAmisulpride and Aripiprzole monotherapy，8-week course of treatment，respectively，one day before treatment，after the start of the first 4 weeks and 8 weeksobservation and evaluation related treatment indicators. Results　Both Amisulpride and Aripiprzole could significantlyreduce schizophrenic patients PANSS scores（P <0.05），but no statistically significant difference between the twogroups（P >0.05）；Amisulpride treatment can lead to the patient serum prolactin levels increased，electrocardiogramQT prolongation，and the group Aripiprzole treatment this had little side effect. Aripiprzole group of patients overall in-cidence of adverse events was significantly lower than amisulpride（P <0.05）.Conclusion　Aripiprzole is more saferthan Amisulpri as an antischizophrenic drug for female patients.

Amisulpride；Aripiprzole；PANSS；Prolactin；QT interval