Journal of International Psychiatry

【摘要】目的：探究多索茶碱联合正压通气（CPAP）治疗睡眠呼吸障碍（OSAHS）合并精神病患者的临床疗效。方法：研究对象选取为2014.1~2017.2之间我院收治的合并精神病的OSAHS患者74例，采用数字表法随机分为联合组和对照组各37例，对照组患者单纯采用CPAP治疗，联合组患者则在CPAP治疗基础上给予患者多索茶碱治疗，两组治疗时间均为4周，对比两组患者治疗前、治疗后的多导睡眠监测系统参数变化情况，并采用匹兹堡睡眠质量指数（PSQI）评价两组患者治疗前后的睡眠质量改善情况。结果：治疗前两组患者的多导睡眠监测系统各项参数对比均无显著差异（P＞0.05），治疗后联合组在呼吸暂停低通气指数（AHI）、睡眠呼吸障碍最低SaO2（LSaO2）、平均SaO2（MSaO2）、SaO2＜90%时间、最长睡眠呼吸障碍时间改善上均显著优于对照组（P＜0.05）；治疗前两组患者的PSQI各维度评分对比均无显著差异（P＞0.05），治疗后联合组在睡眠质量、日间功能、睡眠时间、睡眠障碍及总分改善上均显著优于对照组（P＜0.05）。结论：单纯应用正压通气治疗睡眠呼吸障碍合并精神病患者的疗效有限，联合应用多索茶碱可更有效的改善患者的睡眠呼吸障碍状况，提高患者的睡眠质量，值得在临床上推广和应用。【关键词】睡眠呼吸障碍；精神病；多索茶碱；正压通气[Abstract] Objective: To investigate the clinical efficacy of Doxofylline combined with positive pressure ventilation (CPAP) in the treatment of sleep apnea (OSAHS) with psychosis. METHODS: A total of 74 patients with OSAHS were enrolled in our hospital from 2014.1 to 2017.2. The patients were randomly divided into two groups: the combined group and the control group. The patients in the control group were treated with CPAP alone. The treatment time of the two groups was 4 weeks, compared with the two groups of patients before treatment, after treatment of polysomnography monitoring system parameters, and the use of Pittsburgh Sleep Quality Index (PSQI ) To evaluate the improvement in sleep quality before and after treatment in both groups. Results: There was no significant difference in the parameters of the polysomnography (P> 0.05) between the two groups before treatment, and the lowest in the apnea hypopnea index (AHI), sleep apnea (SaaO2) (P <0.05). There was no significant difference in the scores of PSQI between the two groups before treatment (P> 0.05). There was no significant difference between the two groups (P> 0.05), the mean SaO2 (MSaO2), SaO2 <90% and the longest sleep apnea were significantly better than those in the control group 0.05). After treatment, the combined group was significantly superior to the control group (P <0.05) in sleep quality, daytime function, sleep time, sleep disturbance and total score improvement. Conclusion: The treatment of sleep apnea combined with psychosis in patients with sleep apnea is limited. The combination of doxophylline can improve the sleep apnea and improve the quality of sleep in patients. It is worthy to be popularized and applied in clinical practice.

[Key words] sleep apnea; psychosis; Doxofylline; positive pressure ventilation