Journal of International Psychiatry

【Abstract】 Objective To evaluate the relationship between emotional status and quality of life (QoL) in patients with oral cancer after treatment, and to explore the prognostic factors. Methods A total of 73 patients with oral cancer or nasopharyngeal cancer who underwent at least 1 year of treatment were enrolled in this study. EORTC-QLQ-C30, EORTC-QLQ-H&N35 and Beck Depression Scale II (BDI-II) were used for assessment. Results The overall health status / quality of life score (QoL) (41.7 / 71.9, P <0.001) was higher in the patients with depression, and almost all functions, except the role function, were significantly worse in this population. In addition, the symptoms of QLQ-C30 and QLQ-H&N35condition of the patients with depression were significantly worse (P <0.05). BDI-II score was significantly negative correlated with all function subscale scores and general health status （r=0.341-0.750，all P<0.05）, but it was significantly positive correlated with all symptom subscale scores (except for constipation) （r=0.348—0.793，all P <0.05）. Stepwise multiple linear regression analyses showed that somatic and distress symptoms accounted 46% of the variability. Except the emotional functioning， the overall health status and impairment to social function accounted 64%. Conclusion The quality of life in patients with oral cancer combining with depression is poor. Patients with oral cancer can improve health-related quality of life and / or emotional status through early intervention, and it is necessary to early identify patients with poor health-related quality of life or depressive symptoms through a rapid and friendly questionnaires.[Keywords] Oral cancer; Depression; factor; quality of life

[Keywords] Oral cancer; Depression; quality of life; factor