Journal of International Psychiatry

Objective: The mechanism of Methamphetamine induced psychosis (MAP) is not fully clear. The GPR88 gene encodes GPR88, an orphan G protein-coupled receptor enriched in the striatum and  previously linked to behavioral traits relevant to psychotic symptoms. The aim of this study was to investigate the association of GPR88 gene promoter methylation with methamphetamine induced psychosis. Methods: There were 106 male patients of methyamphetamine induced psychosis, 118 male patients dependent on methyamphetamine without psychosis, and 109 age-matched male controls were recruited in this study. The methylight qPCR were performed to determine GPR88 gene promoter region methylation status.Results: The methylation level of GPR88 gene promoter region is significantly increased in patients of methyamphetamine induced psychosis than patients dependent on methyamphetamine without psychosis and health contral . Conclusions: We report for the first time the significant association of GPR88 gene promoter methylation with methamphetamine induced psychosis .

Methamphetamine induced psychosis; DNA methylation; epigenetic; GPR88 gene