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【Abstract】 Objective To explore the correlation between cognitive dysfunction and anxiety and depression in elderly patients with acute cerebral infarction (ACI).Methods The clinical data of 112 elderly patients with ACI diagnosed and treated in our department of neurology from February 2018 to February 2020 were retrospectively analyzed.According to the Montreal Cognitive Scale (MoCA) score, 112 elderly patients were divided into groups with cognitive dysfunction (43 cases) and those without cognitive dysfunction (69 cases).Compare the clinical data, anxiety score (HAMA), depression score (HAMD) and MoCA scores of the two groups; analyze the impact of anxiety and depression on cognitive dysfunction in elderly ACI patients, and evaluate the early warning of HAMA and HAMD scores for cognitive dysfunction Effect; analyze the correlation between MoCA and HAMA and HAMD scores.Results There were significant differences in age, education, anxiety and depression between the two groups (P <0.05), and the HAMA score and HAMD score of patients with cognitive impairment were higher than those without cognitive impairment (P <0.05).Logistic regression results showed: severe anxiety (OR = 10.696, 95% CI = 2.416 ~ 47.365), severe depression (OR = 6.870, 95% CI = 1.772 ~ 26.643), age> 80 years (OR = 4.973, 95% CI = 1.141 ~ 21.663) is a risk factor for cognitive dysfunction in elderly ACI patients (P <0.05).The score in the group with cognitive dysfunction (18.49 ± 3.33)score was significantly higher than that in the group without cognitive dysfunction [(28.19 ± 1.05)score], the difference was statistically significant (t = 18.557, P <0.05).Pearson correlation showed that MoCA score was negatively correlated with HAMA and HAMD scores (r = -0.334, -0.314, P = 0.000, 0.001, both P <0.05).The ROC curve shows that the AUC of HAMA and HAMD scores for early warning of cognitive dysfunction in elderly ACI patients is 0.726 (95% CI = 0.630 ~ 0.821), 0.709 (0.611 ~ 0.807), with certain accuracy; the optimal cutoff values are 16.5, 25.5; sensitivity, specificity: HAMA scores are 53.5% and 81.2%, and HAMD scores are 51.2% and 84.1%.Conclusion There is a correlation between cognitive dysfunction and anxiety and depression in elderly ACI patients. Elderly ACI patients with severe anxiety and severe depression are more likely to develop cognitive dysfunction, and HAMA and HAMD scores have a certain early warning effect on cognitive dysfunction in these patients .
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