| Abstract |
[Abstract] Objective To explore the correlation between serum alkaline phosphatase (ALP), serum amyloid A (SAA), brain-derived neurotrophic factor (BDNF) and cognitive dysfunction (PSCI) after cerebral infarction. Methods A total of 125 patients with cerebral infarction in our hospital from February 2018 to February 2020 were included and evaluated by national institutes of health stroke scale (NIHSS). They were set as the PSCI group (45 cases) and the non-PSCI group (80 cases) from February 2018 to February 2020 were included and evaluated by national institutes of health stroke scale (NIHSS). They were set as the PSCI group (45 cases) and the non-PSCI group (80 cases) according to whether PSCI occurs. 50 normal people who were admitted to the hospital for physical examination during the same period were selected as the control group, and the serum SAA, BDNF, and ALP levels of each group were detected and the correlation with cognitive dysfunction was analyzed. Results The serum ALP and SAA levels of the PSCI group and the non-PSCI group were significantly higher than those of the control group, and the BDNF level and MMSE score were significantly lower than those of the control group. The differences in serum indexes, MMSE score, and NIHSS score between the PSCI group and the non-PSCI group were statistically significant (P<0.05). There were statistically significant differences in serum ALP, SAA, BDNF levels, NIHSS scores, and MMSE scores in patients with mild, moderate, and severe PSCI in the PSCI group (P<0.05). Serum ALP and SAA levels were significantly negatively correlated with MMSE score, positively correlated with NIHSS score, serum BDNF level was significantly positively correlated with MMSE score, and negatively correlated with NIHSS score (P<0.05). Conclusion The incidence of PSCI is relatively high after cerebral infarction, and serum SAA, BDNF, ALP are closely related to PSCI, which can be used for the early diagnosis and prediction of PSCI after cerebral infarction, and provide theoretical basis for clinical diagnosis and treatment.
|