Journal of International Psychiatry

[Abstract] Objective To study the effect of thoracic paravertebral nerve block on delirium and cognitive function after radical resection of lung cancer. Methods Eighty-eight patients with lung cancer in our hospital from January 2019 to January 2021 were selected as the study subjects, all of whom underwent radical surgery for lung cancer. They were randomly divided into two groups using the number table method. The control group was given conventional general anesthesia; the observation group was given thoracic paravertebral nerve block on the basis of the control group. The two groups of patients with the simple mental state score (MMSE) at 12h, 1d, and 3d after operation were compared. The occurrence of cognitive dysfunction during hospitalization were recorded. Results The 12h, 1d and 3d VAS scores of the observation group were significantly lower than those of the control group (P<0.05). The 12h, 1d, and 3d MMSE scores of the observation group were significantly higher than those of the control group (P<0.05). The incidence of delirium and cognitive dysfunction in the observation group was significantly lower than that in the control group (P<0.05). Conclusion Thoracic paravertebral nerve block can improve the analgesic effect after radical resection of lung cancer and reduce the incidence of postoperative cognitive dysfunction, delirium and other mental complications.

Key words Thoracic Paravertebral Nerve Block; Radical Resection of Lung Cancer; Analgesic Effect; Cognitive Function; Delirium