Journal of International Psychiatry

[Abstract] Objective: To investigate the therapeutic effect of paroxetine on patients with postpartum depression and its changes in neuroendocrine function and sleep quality. Methods: Selection in our hospital between October 2018 and December 2020, 91 patients with postpartum depression during as the research object, using the lottery method is divided into two groups, control group 45 cases give Max Planck for Lin, observation group of 46 cases of application of paroxetine treatment, compared two groups of patients with sex hormone levels and neuroendocrine function, depression, sleep quality and drug safety. Results: Edinburgh postpartum depression (EPDS) scale score and Pittsburgh sleep quality index (PSQI) score in the observation group were significantly lower than those in the control group (P<0.05). The levels of prolactin (PRL) in observation group were lower than those in control group, and the levels of estradiol (E2) and progesterone (P) in observation group were higher than those in control group (P<0.05). The levels of cortisol and adrenocorticotropic hormone (ACTH) in observation group were significantly lower than those in control group, and the levels of 5-hydroxytryptophan (5-HT) in observation group were higher than those in control group (P<0.05). The incidence of ADR in the observation group was 8.69%, lower than that in the control group (15.55%), but the difference was not statistically significant (P>0.05). Conclusion: The application of paroxetine in the treatment of postpartum depression patients can effectively regulate the level of sex hormones, promote the recovery of neuroendocrine function, and improve the sleep quality of patients, so as to relieve the symptoms of depression, with good safety.

【 Key words 】 Postpartum depression; Paroxetine; Sex hormone levels; Depressive mood; The quality of sleep