Journal of International Psychiatry

Objective Observe the body composition differences between patients with first-episode major depressive disorder (FE-MDD), recurrent major depressive disorder (RMDD) and healthy controls (HC) through bioelectrical impedance analysis, and explore the characteristics of body composition of patients with major depressive disorder (MDD) .Methods In this study, 240 outpatients diagnosed with MDD were collected and divided into first-onset depressive disorder (n=120) and recurrent depressive disorder (n=120) according to whether they had their first attack and their medication status; healthy volunteers were selected as the control group (n =120). Collect general information and use a body composition analyzer to measure body composition. Results The phase angle of HC is significantly higher than that of FE-MDD and RMDD; the body mass index, body fat percentage, visceral fat area and waist circumference of RMDD are significantly higher than that of FE-MDD and HC. Regression analysis among the three groups showed that the phase angle (OR= 0.428, 95% Cl: 0.211~0.869) was the protective factor for depression, and the visceral fat area (OR= 1.03, 95% Cl: 1.009~1.052) was the risk of depression Factors (p<0.05).Conclusion Compared with HC, the body composition of FE-MDD and RMDD will have a certain degree of change, and the visceral fat area and phase angle may be one of the influencing factors of MDD. Therefore, clinically, early body composition monitoring should be carried out for patients with depression. Intervention provides an important basis.

Depressive disorder,；Body composition； Visceral fat； Phase angle；Bioelectrical impedance analysis