| Abstract |
[Abstract] Objective To investigate the relationship between homocysteine (Hcy), interleukin-1β (IL-1β), IL-6 and coronary heart disease complicated by depression. Methods A total of 100 patients with coronary heart disease in our hospital from January 2019 to January 2022 were the subjects of this study. Self-rating depression scale (SDS) was used to screen for depression, and they were divided into depression group and non-depression group. Data and serum Hcy, IL-1β, IL-6 levels, binary Logistic regression analysis of the influencing factors of coronary heart disease complicated by depression. Results Thirty-eight cases of depression were screened out of 100 patients with coronary heart disease. There were significant differences in the degree of lesion, age, education level, serum Hcy, IL-1β, and IL-6 between the depression group and the non-depression group (P<0.05). There were no significant differences in gender, hypertension history, diabetes history and smoking history between the two groups (P>0.05). Binary Logistic regression analysis showed that three-vessel disease, age >70 years, serum Hcy, IL-1β, and IL-6 levels were the influencing factors of coronary heart disease complicated by depression. Conclusion The incidence of depression in patients with coronary heart disease is relatively high. Serum Hcy, IL-1β, IL-6 levels, lesion severity, and age are the influencing factors of complication depression.
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