International Journal of Clinical Research

Objective: To analyze the relationship between brain natriuretic peptide (BNP) level and acute myocardial infarction area, in order to better predict the degree of myocardial infarction and judge the prognosis. Methods: 45 patients with acute myocardial infarction who received percutaneous coronary intervention in our hospital in recent 2 years (August 2019 September 2021) were selected as the observation group, and 40 healthy people in the same period were selected as the control group. The BNP content of the two groups of patients was measured by ELISA, and the myocardial infarction area of the two groups was observed by myocardial infarction injury integral method, and the relationship between BNP level and myocardial infarction area was analyzed to determine the prognosis. Results: at admission, the BNP levels of patients in the observation group and the control group were (308.52 ± 124.39) ng/l and (25.66 ± 10.21) ng/l respectively. It can be seen that the BNP level of the observation group was significantly higher than that of the control group, and the difference was statistically significant (p<0.05). Seven days after admission, the BNP levels in the observation group and the control group were (146.87 ± 72.53) ng/l and (25.41 ± 10.68) ng/l respectively. It can be seen that the BNP level in the observation group was significantly lower than that in the admission group, but it was still significantly higher than that in the control group, and the difference was statistically significant (p<0.05); In the observation group, BNP level (327.24 ± 72.95) ng/l and myocardial infarction area (166.73 ± 51.24)% in patients with anterior myocardial infarction were higher than those with inferior myocardial infarction (296.41 ± 69.17) ng/l and (156.03 ± 53.66)% respectively. There was no significant difference between the groups (p>0.05); The correlation analysis between BNP level and myocardial infarction area in patients with acute myocardial infarction showed that the larger the myocardial infarction area, the higher the BNP content, which was positively correlated, and the difference was statistically significant (p<0.05). Conclusion: BNP level in patients with acute myocardial infarction is significantly increased in the acute phase. Although the infarct location has nothing to do with BNP level, the prognosis of anterior myocardial infarction is poor. The author believes that BNP can be used as one of the sensitive indicators to predict the prognosis of patients with acute myocardial infarction; BNP level was positively correlated with infarct size in patients with acute myocardial infarction.

Brain Natriuretic Peptide (Bnp) Level; Acute Myocardial Infarction; Infarct Size; Infarct Site; Relevance; Prognosis