注射鼠神经生长因子治疗慢性多发性周围神经病的疗效分析-国际内科前沿杂志-CSCIED科技核心评价数据库-手机版

注射鼠神经生长因子治疗慢性多发性周围神经病的疗效分析

Efficacy analysis of injection of mouse nerve growth factor in the treatment of chronic polyneuropathy

ES评分 0 浏览量：907 下载量：0

DOI	10.12208/j. ijim.20220081
刊名	国际内科前沿杂志 International Journal of Internal Medicine
年，卷(期)	2022, 3(3)
作者	彭勃*,
作者单位	镇江市第一人民医院江苏镇江 ;
摘要	探讨慢性多发性周围神经病（CPP）患者注射鼠神经生长因子（mNGF）的疗效。方法共计纳入对象60例，均为CPP患者，双色球法分为两组，对照组用基础治疗，观察组则加mNGF注射治疗，对比疗效。结果治疗前两组MTT评分、SDR评分、VAS评分、生活质量评分比较无明显差异（P>0.05），治疗结束，观察组MTT评分、生活质量评分更高，而SDR评分、VAS评分更低，差异显著（P<0.05）；两组不良反应无明显差异（P>0.05）。结论 CPP予以mNGF注射治疗，可更好地改善患者的运动功能与感觉障碍，减轻患者的疼痛程度，促进患者生活质量提高，但不会明显增加不良反应，值得应用。
Abstract	Objective To investigate the efficacy of mouse nerve growth factor (mNGF) injection in patients with chronic polyneuropathy (CPP). Methods A total of 60 subjects, all of whom were CPP patients, were divided into two groups by the two-color ball method. The control group was treated with basic treatment, and the obser- vation group was treated with mNGF injection to compare the curative effects. Results There was no significant difference in MTT score, SDR score, VAS score and quality of life score between the two groups before treatment (P>0.05). After treatment, the MTT score and quality of life score of the observation group were higher, while the SDR score and VAS score were lower. The difference was significant (P<0.05); there was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion CPP with mNGF injection therapy can better improve the motor function and sensory disturbance of patients, reduce the pain degree of patients, and improve the quality of life of patients, but it will not significantly increase the adverse reactions, and it is worthy of application.
关键词	慢性多发性周围神经病；鼠神经生长因子；MTT评分；SDR评分；生活质量
KeyWord	Chronic polyneuropathy; Mouse nerve growth factor; MTT score; SDR score; Quality of life
基金项目
页码	49-52

参考文献
相关文献

[1] 刘荣. 注射鼠神经生长因子治疗慢性多发性周围神经病的疗效分析[J]. 临床医药文献电子杂志,2018,5(61):78.

[2] 孟凯涛. 鼠神经生长因子联合甲钴胺治疗糖尿病周围神经病对患者肌电图血脂及VitB12水平的影响[J]. 河北医学,2021,27(11):1812-1817.

[3] 娄华,逄涛,梅运涛. 鼠神经生长因子配合甲钴胺治疗慢性酒精中毒性周围神经病效果及对患者神经传导速度的影响[J]. 临床研究,2021,29(3):56-57.

[4] 马永伟. 鼠神经生长因子配合甲钴胺治疗慢性酒精中毒性周围神经病效果及对患者神经传导速度的影响[J].包头医学院学报,2018,34(4):42-43,81.

[5] 梁冬蕾,胡志兵,杨志前,等. 鼠神经生长因子治疗慢性正己烷中毒周围神经病疗效评价[J]. 中国卫生标准管理,2017,8(21):69-71.

[6] 张俊英,王宇彤. 鼠神经生长因子联合甲钴胺治疗糖尿病周围神经病的疗效及安全性观察[J]. 神经损伤与功能重建,2017,12(5):461-462.

[7] 李洁,黄春,许淑贤,等. 甲钴胺联合鼠神经生长因子治疗糖尿病周围神经病的疗效及对神经传导速度的影响[J].贵州医药,2018,42(12):1431-1432.

[8] 邹志斌,郭世文,邹国荣,等. 大鼠脑出血后不同时期神经营养因子受体p75、神经生长因子前体、酪氨酸激酶A的表达及其与细胞凋亡的相关性[J]. 国际神经病学神经外科学杂志,2019,46(2):136-140.

[9] 刘明生,崔丽英. 欧洲神经病学会/周围神经协会2021慢性炎性脱髓鞘性多发性神经根神经病指南的变化[J]. 中华神经科杂志,2022,55(3):181-186.

[10] 冯园,卢祖能. 静脉注射免疫球蛋白对慢性炎性脱髓鞘性多发性神经根神经病作用机制的研究进展[J]. 神经损伤与功能重建,2022,17(2):100-102.

引用本文

彭勃*. 注射鼠神经生长因子治疗慢性多发性周围神经病的疗效分析 [J]. 国际内科前沿杂志. 2022; 3; (3). 49 - 52.

文献评论

相关学者

相关机构