International Research in Chinese Medicine

Objective The injury of gastrointestinal cells and the destruction of gastrointestinal mucosal barrier in traumatic shock lead to the change of emergency regulation ability and internal environment. This study aims to clarify the effect of traumatic hemorrhagic shock on the expression of intestinal inflammatory factors and heat shock proteins in rats through animal experiments. Methods: Twenty four SD rats were randomly divided into normal control group and traumatic hemorrhagic shock group. The intestinal mucosa was taken and the inflammatory factors IL-6 and IL-1 were measured β、 TNF- α And HSP-70. Results: After traumatic hemorrhagic shock, inflammatory factors and heat shock proteins in rats were significantly increased. IL-6、IL-1 β、 TNF- α HSP-70 and HSP-70 increased 2.15, 23.9, 124.7 and 0.57 times respectively. Compared with the normal control group, there were significant differences (P<0.05). Conclusion: After traumatic hemorrhagic shock, the inflammatory reaction of gastrointestinal tract is abnormally increased, and the intensity of stress response is significantly enhanced. Shi Guanyins "intestinal failure" or "shock intestine" plays an important role in the occurrence and development of multiple organ dysfunction.

Traumatic hemorrhagic shock, shock intestine, inflammatory factors, heat shock proteins