扎来普隆片、佐匹克隆片和艾司唑仑片治疗失眠症的对照研究
A comparison study of zaleplon, zopiclone and estazolam in the treatment of insomnia
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2016, 43(5) |
| 作者 |
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| 作者单位 |
山东省烟台市莱州荣军医院 ;
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| 摘要 |
【摘要】目的:评价扎来普隆片、佐匹克隆片和艾司唑仑片治疗失眠症的疗效和不良反应。方法:将156例符合ICD-10非器质性失眠症标准的患者随机分为扎来普隆组（n=50）、佐匹克隆组（n=53）和艾司唑仑组（n=53），治疗期2周。疗效观察指标采用睡眠障碍量表（SDRS）和药物副作用量表（TESS）评价安全性。结果:扎来普隆组、佐匹克隆组和艾司唑仑组有效率分别为96.00%、94.34%、96.23%，三组SDRS评分均呈显著降低（P<0.05）；不良反应发生率扎来普隆组和佐匹克隆组比较差异无统计学意义（P>0.05）。但二者显著低于艾司唑仑组（P<0.05）。结论:扎来普隆、佐匹克隆和艾司唑仑具有相似的疗效，但扎来普隆和佐匹克隆不良反应少于艾司唑仑。
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| Abstract |
【Abstract】 Aim: To evaluate the efficacy and safety of zaleplon compared with zopiclone and estazolam. Method: 156 cases with insomnia were enrolled,the zaleplon group (n=50),the zopiclone group (n=53) and the estazolam group (n=53) were treated for 14 days.The thera pentic effects and adverse reactions were assessed with the Sleep Dysfunction Rating Scale(SDRS) and Treatment Emergent Sympion Scale (TESS). Results:zaleplon, zopiclone group and efficient estazolam group were 96.00%, 94.34%, 96.23%, three groups of SDRS scores were significantly lower (P<0.05); Incidence of adverse reaction of drugs and zopiclone group, there was no statistical significance (P>0.05). But both significantly lower than that of estazolam group (P<0.05). Conclusion: zaleplon, zopiclone and estazolam similar curative effect, but zaleplon and zopiclone adverse reaction less than estazolam.
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| 关键词 |
【关键词】扎来普隆；佐匹克隆；艾司唑仑；失眠症；疗效；安全性
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| KeyWord |
【key words】 zaleplon;zopiclone; estazolam; Insomnia; effectiveness; safety
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| 基金项目 |
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| 页码 |
836-838 |
邹旭明*.
扎来普隆片、佐匹克隆片和艾司唑仑片治疗失眠症的对照研究 [J].
国际精神病学杂志.
2016; 43; (5).
836 - 838.