Journal of International Psychiatry

【Abstract】 Objective To comparatively analyze the effects of different long-term use of atypical antipsychotics regimens in the treatment of organic mental disorders and effect on body mass, lipid and glucose metabolism. Methods 86 patients with organic mental disorders who met the inclusion criteria were randomized into observation group and control group, 43 cases in each. The observation group was treated with risperidone while the control group was treated with olanzapine. The clinical curative effects, adverse reactions, body mass before and after treatment, blood glucose and blood lipid, etc. were compared between the two groups. Results There was no significant difference in total effective rate between the two groups (P > 0.05). The body mass, FPG and 2hFPG in the control group after 3 months of treatment were significantly higher than those before treatment (P < 0.05), while there were no significant differences in the indexes mentioned above in the observation group before and after treatment (P > 0.05). After 3 months of treatment, LDL-C, leptin and HOMA-IR in the two groups were significantly higher than those before treatment (P < 0.05), but there was no significant difference between the two groups (P > 0.05). The incidence rates of gaining weight, sleepiness, insomnia and elevated prolactin in the observation group were significantly different from those in the control group (P < 0.05). Conclusion The effects of long-term administration of risperidone and olanzapine in the treatment of organic mental disorders are similar. They have their own characteristics in terms of adverse reactions. However, compared with olanzapine, long-term use of risperidone has little influence on patients body mass, lipid and glucose metabolism indexes. Therefore, risperidone is preferred in treatment.

【Key words】 Organic mental disorders; Atypical antipsychotics; Body mass; Lipid and glucose metabolism