Journal of International Psychiatry

【Abstract】Objective: To investigate the relationship of Serum sex hormone, 5-HT levels of anxiety and depression in perimenopausal women。Methods: 180 cases of non-organic disease and other physical disorders in perimenopausal women were divided into control group (n=54), depression group (n=38), anxiety group (n=42) and comorbid depression and anxiety group (n=46) based on self-rating anxiety scale (SAS) and Self-Rating Depression Scale (SDS) from April 2015 to April 2016。The levels of estradiol (E2), progesterone (P), prolactin (PRL), follicle stimulating hormone (FSH), testosterone (T) , luteinizing hormone (LH) and 5-HT were determed.Results: The levels of FSH, LH, PRL of four groups were had no significant difference (P>0.05)The levels of E2、P、T、5-HTof four groups had significant difference (P<0.05). Pearson correlation coefficient，serum P had negatively correlation with SDS , SAS (P <0.05), serum T had positively correlation with SDS , SAS (P <0.05), serum 5-HT and SDS was positively correlated (P <0.05).Conclusion: Hormone perimenopausal depression and anxiety occur are closely related, 5-HT and sex hormones may affect the common occurrence of depression.

【Keywords】Sex hormones; Serotonin; Climacteric; Depression; Anxiety disorder