Journal of International Psychiatry

[Abstract]Objective To study the influence factor affecting the incidence of mental disorders induced by glucocorticoid, to provide guidance for the clinical application of glucocorticoid. Methods 560 patients treated with glucocorticoid were selected as objects. The relationship between general conditions and incidence of mental disorders of patients were observed and analysed. Results The incidence of mental disorders was 23.93% in this study. Univariate analysis showed that gender, occupation, education, hormone application time and severity of illness on the incidence of mental disorders had no effect (P > 0.05). Multivariate Logistic analysis showed that the hormone application time, hormone type and steroid dose are risk factors leading to mental disorder (P < 0.05 or 0.01). Conclusion Glucocorticoid treatment can lead to mental disorders, dexamethasone, age, hormone application time are risk factors, which should cause clinician to take seriously.

[Key Words]Glucocorticoid; Mental Disorder; Correlation