急性心肌梗死经皮冠状动脉介入治疗后伴焦虑抑郁患者ET-1、PAI-1及hs-CRP浓度分析-国际精神病学杂志-CSCIED科技核心评价数据库-手机版

急性心肌梗死经皮冠状动脉介入治疗后伴焦虑抑郁患者ET-1、PAI-1及hs-CRP浓度分析

ET-1, PAI-1 and hs-CRP concentration analysis of AMI complicated with anxiety and depression after PCI

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DOI
刊名	国际精神病学杂志 Journal of International Psychiatry
年，卷(期)	2016, 43(5)
作者	张海良,丁鹏,解飞,贺鹏辉,王西辉*,
作者单位	西安医学院第二附属医院 ; 解飞 ;
摘要	【摘要】目的：探讨急性心肌梗死（AMI）患者经皮冠状动脉介入治疗（PCI术）后伴焦虑抑郁对患者内皮素-1（ET-1）、人纤溶酶原激活物抑制因子-1（PAI-1）以及高敏C反应蛋白（hs-CRP）浓度的影响，并分析PCI术后合并焦虑抑郁与ET-1、PAI-1和hs-CRP之间的关系。方法：选取我院2013年9月至2015年9月期间在接受PCI术治疗的AMI患者200 名，按照汉密尔顿焦虑及抑郁量表将患者分成介入术后伴焦虑抑郁组（n=103）和介入术后无焦虑抑郁组（n=97）。另选100例未行PCI术治疗患者（对照组）。应用ELASE法测定血清当中内ET-1、PAI-1水平，采用速率散射比浊法测定血清当中hs-CRP水平，并对数据进行统计分析。结果：PCI术患者血清ET-1、PAI-1及hs-CRP水平明显高于对照组，且术后伴焦虑抑郁患者明显高于术后无焦虑抑郁的患者，差异具有显著性。结论：PCI术和焦虑抑郁状态均影响患者ET-1、PAI-1及hs-CRP水平。
Abstract	【Abstract】Objective: To investigate ET-1, PAI-1 and hs-CRP concentration of AMI (acute myocardial infarction) complicated with anxiety and depression after PCI (percutaneous coronary intervention). Methods: 200 cases of PCI patients in our hospital from September 2013 to September 2015 were divided into group with anxiety and depression (n=103) and group without anxiety and depression (n=97), and 100 cases without any PCI were taken as control group. ELASE method was applied in the determination of serum ET-1 and PAI-1 level, rate scatter turbid assays was used for the determination of serum hs-CRP level. Results: The serum ET-1, PAI-1 and hs-CRP levels of PCI patients were significantly higher than that of control group, and PCI combined with postoperative anxiety and depression in patients was significantly higher after PCI without anxiety and depression. Conclusion: PCI technique and the state of anxiety and depression have significant impact on serum ET-1, PAI-1 and hs-CRP levels.
关键词	【关键词】急性心肌梗死；PCI；焦虑抑郁；ET-1；PAI-1；hs-CRP
KeyWord	【Keywords】AMI; PCI; Anxiety and depression; ET-1; PAI-1; hs-CRP
基金项目
页码	854-856

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张海良,丁鹏,解飞,贺鹏辉,王西辉*. 急性心肌梗死经皮冠状动脉介入治疗后伴焦虑抑郁患者ET-1、PAI-1及hs-CRP浓度分析 [J]. 国际精神病学杂志. 2016; 43; (5). 854 - 856.

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