| Abstract |
[Abstract] Objective: To analyze obstructive sleep apnea hypopnea syndrom cerebral white matter structural damage correlation with cognitive dysfunction. Methods: During November 2014 to October 2015, 71 cases of patients with snoring in our hospital were researched, according to the apnea hypoventilation index (AHI), patients can be divided into the following groups: 12 patients with sleep apnea, pure mild OSAHS group with 19 cases, moderate OSAHS group with 17 cases, 23 cases of severe OSAHS group. Compare the clinical data of four groups of the object of study, sleep respiratory parameters [apnea hypoventilation index (AHI), pulse oxygen saturation < 90% of the time the percentage of the total sleep time (TS90 %), pulse oxygen saturation (MSaO2) on average, minimum pulse oxygen saturation (LSaO2), sleep related breathing awareness index (RI), oxygen reduction index (ODI)], focal high signal around lateral ventricle (PVH) score, simple intelligent state scale (MMSE) score, Montreal cognitive assessment scale (MoCA) score, analyze PVH score and the correlation of the parameters. Results: The four groups of gender, education time, body mass index had no significant difference (P > 0.05), between the four groups of AHI, ODI, RI, TS90 %, LSaO2, MSaO2 had statistical significant difference(P < 0.05), the comparison between the two groups have statistical significance (P < 0.05). Four groups of PVH score, MMSE score, MoCA score had statistically significant differences (P < 0.05), the comparison between the two groups have statistical significance (P < 0.05). PVH score and MoCA scores, MMSE score, LSaO2, MSaO2 negatively correlated (P < 0.05), PVH score and AHI, ODI, RI parameters were positively correlated (P < 0.05). Conclusion: Patients with OSAHS of cerebral white matter structure damage,which have a close correlation between the cognitive dysfunction.
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