| Abstract |
Abstract Objective: To inveterate the relationship of serum estrogen and 5-HT with postpartum depression(PPD).Methods: 680 cases of women delivered in our hospital and received follow-up from January 2015 to 2016 January were chosen, who were assessed with Edinburgh Postpartum Depression scale(EPDS) within 42 days after childbirth,the patients were diagnosed with PPD as the observation group, 80 cases in another 600 cases of normal women were randomly selected as a control group, the serum levels of Estradiol (E2) and 5-HT in the two groups were detected and compared between the two groups.Results: The incidence of PPD was 11.76% (80/680);The EPDS HAMD, HAMA scores in observation group were significantly higher than that in the control group(P<0.05); The serum levels of E2 and 5-HT was (63.85±0.23) pg/mL, (1.02±0.23) μmol/L in observation group, higher than that of (126.84±0.46) pg/mL, (2.65±0.37) μmol/L in control group, the differences were statistically significant (P<0.05); The serum E2 level was significantly negative related with EPDS, HAMD, HAMA scores(r=-0.52, -0.75, -0.66, P<0.05), the 5-HT level was significantly negative related with EPDS, HAMD, HAMA scores (r=-0.18, -0.29, -0.21, P<0.05). Conclusion: The reduce of serum E2 and 5-HT may be one of the mechanisms of PPD,detection of serum E2 and 5-HT levels can be effective for the prediction, diagnosis and intervention of PPD.
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