Journal of International Psychiatry

Abstract: Objective to investigate the clinical effects of dexmedetomidine and propofol treated in patients with heart postoperative surgery. Methods 150 patients with cardiac surgery who were selected and randomly included in dexmedetomidine midazolam group (72 cases) and propofol group (68 cases), were compared between the two groups in ICU stays, delirium rate, adverse events rate differences. Results ICDSC scores in two groups was significantly decreased compared to before treatment (P<0.05); ICDSC scores in dexmedetomidine midazolam group were significantly lower than propofol group (P<0.05). the incidence of delirium in dexmedetomidine group was 11.11%, ICU stays was 9.35 days were significantly lower than that in propofol group of 16.18% and 12.41 days (P<0.05). Hypotension (30.56%), tachycardia slow (16.67%), tracheal intubation (4.17%) incidence rate in dexmedetomidine midazolam group was significantly lower than that in propofol group with significant difference (P< 0.05). Conclusion Both dexmedetomidine and propofol can effectively treat patients with postoperative delirium. For reducing side effects, dexmedetomidine has significantly advantages and worthy of recommendation for clinical practice.

Keywords: Dexmedetomidine; Propofol; delirium