International Journal of Nursing Research

Objective To investigate the application effect of modified subcutaneous injection technique in bortezomib therapy for patients with multiple myeloma, and to evaluate its influence on local adverse reactions, pain intensity and treatment safety, so as to provide evidence for optimizing clinical nursing practice. Methods A total of 90 multiple myeloma patients treated with subcutaneous bortezomib in the hematology department of a tertiary hospital in November 2024 were enrolled and randomly divided into observation group and control group, with 45 cases in each group. The control group received routine subcutaneous injection, while the observation group was given modified injection technique with air-lock and precise abdominal site selection. Subcutaneous hemorrhage, pain score, complications (induration, hematoma) and drug residual rate were compared between the two groups. Results The incidence of severe subcutaneous hemorrhage in the observation group was 0, significantly lower than 11.1% in the control group (P<0.05). The VAS score in the observation group was (2.1±0.8), significantly lower than (4.3±1.2) in the control group (P<0.001). The total complication rate was 6.7% in the observation group and 24.4% in the control group (P<0.05). The drug residual rate was also significantly lower in the observation group (P<0.001). Conclusion The modified subcutaneous injection technique can significantly reduce local adverse reactions and pain caused by bortezomib, decrease drug residue, and improve patient tolerance and comfort. It is simple, safe and consistent with clinical guidelines and evidence-based nursing, which is worthy of clinical promotion.

Multiple myeloma; Bortezomib; Modified subcutaneous injection; Air-lock technique; Adverse reactions; Evidence-based nursing