“天癸一号方”对抗精神病药物所致药源性闭经患者情绪的影响

The emotional impact of Drug-induced amenorrhea who were caused by antipsychotic treating by

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2016, 43(6)
作者
作者单位

衡水市精神病医院中西医结合科 ;
衡水市精神病医院护理部 ;
衡水市精神病医院精神科 ;

摘要
【摘要】目的:研究“天癸一号方”在治疗抗精神病药物引起的药源性闭经患者时会对患者的情绪造成什么影响。方法:选取2015年1月-2016年2月在本院治疗抗精神病药物所致药源性闭经的女性患者,共96例。通过随机的方法对患者进行分组,平均分成治疗组和对照组。对照组使用常规的抗精神病药物进行治疗,而治疗组则在使用常规药物的同时增加“天癸一号方”共同进行治疗。治疗以十四天为一疗程,患者需要接受连续四个疗程的治疗。在治疗结束后,需要对患者的临床疗效、内分泌调节情况和情绪状态进行研究及比较。结果:治疗结束后,结果如下“治疗组的临床疗效的总有效率(89.6%)要明显高于对照组(72.9%),差异显著,可以运用到统计学分析中。内分泌指标上,两组的PRL在治疗后均有一定程度的下降,同时E2、LH等激素指标则出现上升的情况。治疗组与对照组相比,治疗前后各激素指标的差值更加大;同时,治疗后两组之间激素指标的变化也具有显著性差异,并且差异可以运用到统计学分析中(P<0.05)。最后,在情绪指标上,两组在治疗后使用HAMA和HAMD两个量表对患者情绪进行评估,根据比对可以发现,在HAMA两表上,两组的情绪评分上虽然有差异,但是并没有统计学意义。在HAMD量表中,评分越低表示情绪状态越好。在研究结果中,对照组的评分要明显高于治疗组,两组的评分具有显著性差异,并且差异可以运用到统计学分析中(P<0.05)。结论:“天癸一号方”对抗精神病药物导致的药源性闭经患者的情绪有着良好的治疗效果,对于改善患者情绪有良好的作用。
Abstract
【Abstract】Objective: To observe the "Tiangui 1" caused by antipsychotic drugs in the treatment of drug-induced amenorrhea in patients with emotional effect. Methods: 96 patients were selected from January 2015 to February 2016 in the hospital treatment of antipsychotic drugs induced by drug amenorrhea in female patients, a total of 96 patients,than we use the method of random to divide the patients into the treatment group and the control group. Control group was given conventional psychopharmacological treatment, while the treatment group on the basis of the control group increased Tiangui, a recipe for treatment, we use 14 days for a course of treatment, continuous treatment for 4 months after comparative observation of the clinical curative effect of two groups of patients, endocrine changes and mental or emotional state indicators. Results: After the end of the four courses of treatment, according to the results you can see, in the evaluation of clinical efficacy, the treatment group’s total effective rate is higher than the control group, the total effective rateof control group is only 72.9%, but the total effective rate of treatment group is 89.6%, hasstatistical significance (P<0.05). In gynecological endocrine index, the treatment group’s effect is better than the control group, and the difference has statistical significance (P<0.05). In terms of emotional state, after two rating scale of two groups of patients, found that for HAMA scale, the score difference between two groups is not significant, dose not have statistically significant; But in HAMD scale, there is obvious difference between two groups. The total score of the treatment group is lower than the control group, and has statistical significance (P<0.05). Conclusion: The effect of Tiangui No.1 Decoction "in the treatment with antipsychotic drugs induced drug-induced amenorrhea good, and to improve the risk of emotions has good effect.
关键词
【关键词】天癸一号方;药源性闭经;情绪
KeyWord
【Keywords】Tiangui No. 1;drug-induced amenorrhea; emotion
基金项目
页码 1025-1028
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赵幸福*,张士巧,乔云栓,郗玲燕,张素允,崔卫东. “天癸一号方”对抗精神病药物所致药源性闭经患者情绪的影响 [J]. 国际精神病学杂志. 2016; 43; (6). 1025 - 1028.

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