Journal of International Psychiatry

【Abstract】 Objective: To compare the clinical efficacy and safety of escitalopram and citalopram combined with antiepileptic drugs in treatment of epilepsy with depression.Methods: From March 2011to March 2016, 92 cases of epilepsy with depression patients in department of internal neurology[Anddepartment of Neurosurgery] in our hospital were collected,they were randomly divided into two groups: observation group (46 cases) received escitalopram combined with sodium valproate therapy, control group (46 patients) received citalopram with sodium valproate therapy.The scores of Hamilton Depression Rating Scale 17-item (HAMD) and Patient Health Questionnaire 9-item Depression Scale(PHQ-9) before and after1 week,2week and 4week of treatment were evaluated,the clinical efficacy and adverse reactions between the two groups were compared.Results: After 1 week, 2 weeks, 4 weeks of treatment , the scores of HAMD-17 and PHQ-9 in observation group were statistically lower than the control group(P<0.05);The total effective rate in observation group was 95.65% (44/46), significantly higher than the 80.43% (37/46) in control group, the difference between the two groups was statistically significant (P<0.05) ; The adverse reactions rate in observation group was 6.52% (3/46), lower than 15.22% (7/46) in the control group, but the difference was not statistically significant between the two groups (P>0.05). Conclusion: Escitalopram combined with antiepileptic drugs to treat epilepsy with depression is more effective than citalopram, escitalopram takes effect faster and has higher safety, should be widely applied.

【Key words】 Epilepsy; Depression; Antiepileptic drugs; Dscitalopram; Citalopram